Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice

Biochemical and Biophysical Research Communications
Takashi MatsunagaShigehiro Ohdo

Abstract

One approach to increasing pharmacotherapy effects is administering drugs at times of day when they are most effective and/or best tolerated. Circadian variation in expression of pharmacokinetics- and pharmacodynamics-related genes was shown to contribute to dosing time-dependent differences in therapeutic effects of small molecule drugs. However, influence of dosing time of day on effects of high molecular weight formulations, such as drugs encapsulated in liposomes, has not been studied in detail. This study demonstrates that blood pressure rhythm affects dosing time-dependent variation in effects of high molecular weight formulations. Systolic blood pressure in sarcoma 180-bearing mice showed significant 24-h oscillation. Intratumoral accumulation of fluorescein isothiocyanate-labeled bovine serum albumin (FITC-BSA), an indicator of tumor vascular permeability, varied with dosing time of day, matching phases of blood pressure circadian rhythm. Furthermore, intratumoral accumulation of liposome-encapsulated oxaliplatin (Lipo-L-OHP) increased with increases in systolic blood pressure. Our findings suggest that circadian blood pressure oscillations may be an important factor to consider in dosing strategies for macromolecular d...Continue Reading

References

Jul 8, 1992·Biochimica Et Biophysica Acta·D NeedhamD D Lasic
Dec 16, 1997·American Journal of Hypertension·T OhkuboS Hisamichi
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S K HobbsR K Jain
Nov 10, 2001·Annual Review of Biomedical Engineering·R K Jain
Aug 27, 2002·Developmental Cell·J D Alvarez, Amita Sehgal
Jun 19, 2004·The Journal of Pharmacology and Experimental Therapeutics·Naoya MatsunagaShigehiro Ohdo
Feb 14, 2006·Nature Genetics·Trey K SatoJohn B Hogenesch
Mar 3, 2007·Drug Metabolism and Pharmacokinetics·Shigehiro Ohdo
Apr 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Vera FarahMariana Morris
Jul 21, 2007·International Journal of Pharmaceutics·Ryo SuzukiKazuo Maruyama
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kwangjae ChoDong M Shin
Aug 12, 2008·International Journal of Pharmaceutics·Shuxian SongYuhong Xu
Aug 30, 2008·American Journal of Physiology. Renal Physiology·Sungmi ParkLisa M Harrison-Bernard
Oct 30, 2009·Current Opinion in Nephrology and Hypertension·Rajiv Agarwal
Sep 30, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven K LibuttiLawrence Tamarkin
Jul 5, 2011·Chronobiology International·Constance AhowessoFrancis Lévi
Nov 21, 2013·Cancer Research·Hiroyuki OkazakiShigehiro Ohdo
Mar 21, 2015·Biochemical and Biophysical Research Communications·Pingping LinMingchun Li
Apr 15, 2016·Sleep Medicine Reviews·Michael H SmolenskyFrancesco Portaluppi
Oct 6, 2017·Science Translational Medicine·Matthias Pinter, Rakesh K Jain
Oct 19, 2017·Cancer Research·Fumiyasu OkazakiHideto To

❮ Previous
Next ❯

Citations

Aug 1, 2019·Advanced Functional Materials·Xia CaoYu Shrike Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.