Angiotensin II regulates phosphoinositide 3 kinase/Akt cascade via a negative crosstalk between AT1 and AT2 receptors in skin fibroblasts of human hypertrophic scars

Life Sciences
Hong-Wei LiuXiao-Bing Fu

Abstract

Angiotensin II (Ang II) stimulation has been shown to regulate proliferation of skin fibroblasts and production of extracellular matrix, which are very important process in skin wound healing and scarring; however, the signaling pathways involved in this process, especially in humans, are less explored. In the present study, we used skin fibroblasts of human hypertrophic scar, which expressed both AT1 and AT2 receptors, and observed that Ang II increased Akt phosphorylation and phosphoinositide 3 kinase (PI 3-K) activity. In addition, the Ang II-induced Akt phosphorylation was blocked by wortmannin, a PI 3-K inhibitor. This Ang II-activated PI 3-K/Akt cascade was markedly inhibited by valsartan, an AT(1) receptor-specific blocker, whereas it was enhanced by PD123319, an AT(2) receptor antagonist. On the other hand, the Ang II- or EGF-induced activation of PI 3-K/Akt was strongly attenuated by AG1478, an inhibitor of epidermal growth factor (EGF) receptor kinase. Moreover, Ang II stimulated tyrosine phosphorylation of EGF receptor and p85alpha subunit of PI 3-K accompanied by an increase in their association, which was inhibited by valsartan, and enhanced by PD123319. The Ang II-induced transactivation of EGF receptor resulted i...Continue Reading

References

Nov 1, 1992·The Journal of Investigative Dermatology·M BabuN Oliver
Sep 16, 1992·Biochemical and Biophysical Research Communications·B KimuraM I Phillips
Jul 15, 1992·Biochemical and Biophysical Research Communications·R GyurkoM I Phillips
Oct 1, 1994·The Journal of Investigative Dermatology·M HaisaG R Grotendorst
Jan 1, 1996·The Journal of Laboratory and Clinical Medicine·Y Sun, K T Weber
Nov 1, 1996·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·M AbikoG S Dizerega
Mar 1, 1997·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·G NickenigA Sachinidis
Jun 1, 1997·The Surgical Clinics of North America·E E TredgetA Ghahary
Mar 12, 1998·Molecular Medicine Today·T L Tuan, L S Nichter
Apr 3, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·M IvarssonK Rubin
Sep 17, 1999·The Journal of Biological Chemistry·B CuevasG B Mills
Jul 27, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·K RodgersG Dizerega
Jan 13, 2004·Experimental Dermatology·Kathleen E RodgersGere diZerega
Feb 28, 2004·Experimental Dermatology·U Muscha SteckelingsMetin Artuc
Jul 6, 2004·American Journal of Hypertension·Michelangelo SartoriAndrea Semplicini
Oct 29, 2004·The American Journal of Pathology·Hikaru TakedaShigeo Kondo
Feb 12, 2005·Endocrinology·Chi-Chang JuanLow-Tone Ho
Apr 1, 1997·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·K RodgersG diZerega

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Citations

Aug 30, 2013·Plastic and Reconstructive Surgery·Hakan UzunAycan Uğur Kayikçioğlu
Oct 27, 2011·American Journal of Physiology. Endocrinology and Metabolism·Jeong-A KimJames R Sowers
Jun 20, 2007·Experimental Dermatology·Mara FumagalliCarlotta Castagnoli
Apr 17, 2007·Journal of Dermatological Science·Hong-Wei LiuJian-Fu Li
Nov 13, 2013·Biochemical and Biophysical Research Communications·Yuko Matsuura-HachiyaToshio Nishiyama
Sep 18, 2012·The American Journal of Pathology·Farhatullah SyedArdeshir Bayat
Oct 28, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tosan EhanireHoward Levinson
Jun 26, 2013·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Meng RenLi Yan
Apr 8, 2009·Journal of Burn Care & Research : Official Publication of the American Burn Association·Vincent Ashley Gabriel
Feb 19, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuan-Yuan LuPing-Jin Gao
Sep 12, 2020·Journal of Plastic Surgery and Hand Surgery·Muzaffer KurtAysel Caglar

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