Angiotensin II sensitivity in nonpregnant formerly preeclamptic women and healthy parous controls

Journal of the Society for Gynecologic Investigation
Marc E A SpaandermanLouis L H Peeters

Abstract

In women prone to develop hypertensive complications, vascular reactivity fails to decrease in early pregnancy. Since hypertensive syndromes of pregnancy seem to be superimposed on a preexisting disorder, we tested the hypothesis that in formerly preeclamptic women, as compared to healthy parous controls, circulatory reactivity to angiotensin II is enhanced in the follicular phase of the menstrual cycle. Sixty formerly preeclamptic women were subdivided into a hypertensive (HYPERT, n = 14), a normotensive thrombophilic (THROMB, n = 26), and a normotensive nonthrombophilic (ASYMPT, n = 20) subgroup. In these women and in 11 healthy parous controls we assessed at least 5 months postpartum at day 5 (+/-2) of the menstrual cycle the following variables: body weight, height, plasma volume, reactivity to infused angiotensin II of arterial blood pressure, heart rate, glomerular filtration rate (GFR), effective renal blood flow, and the hormones of the renin-angiotensin-aldosterone (RAAS) axis. At baseline, THROMB did not differ from controls. In contrast, ASYMPT exhibited slight overweight, reduced plasma volume, and reduced renal blood flow. HYPERT much resembled ASYMPT except for the overweight, renal perfusion, and GFR. Infusion of...Continue Reading

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Jan 29, 2000·American Journal of Obstetrics and Gynecology·M E SpaandermanL L Peeters

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Citations

Nov 9, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anne Marijn van der GraafA Titia Lely
Feb 17, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nina D PaauwA Titia Lely
Feb 20, 2015·American Journal of Physiology. Renal Physiology·Tsjitske J ToeringA Titia Lely
Jan 25, 2017·BioMed Research International·Abimael González-HernándezCarlos M Villalón

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