PMID: 3215390Dec 1, 1988Paper

Angiotensin II-stimulated changes in calcium metabolism in cultured glomerulosa cells

Molecular and Cellular Endocrinology
R E Kramer

Abstract

Studies were performed to evaluate the relationships between the effects of angiotensin II on calcium metabolism and cytosolic free calcium concentration in primary monolayer cultures of bovine adrenal glomerulosa cells. As noted previously (Kramer (1988) Am. J. Physiol. (in press], angiotensin II produced rapid dose-dependent increases in cytosolic calcium characterized by both an initial transient component and a secondary sustained component. In the absence of extracellular calcium, angiotensin II produced an initial increase in cytosolic calcium comparable to that produced in the presence of calcium, but failed to maintain a sustained calcium signal. The initial, angiotensin-stimulated increase in cytosolic calcium was inhibited by dantrolene and 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate (TMB-8) in a concentration-dependent fashion. The onset of the angiotensin-stimulated calcium signal was accompanied by a dose-dependent increase in the rate of calcium efflux that achieved a maximum within 2-3 min and then declined to a level 2.5-3 times that from control cells. The initial rate of calcium influx was also increased about 2.5-fold by angiotensin II, an effect that was only apparent in cells that had been treated w...Continue Reading

References

Nov 1, 1986·The American Journal of Physiology·A Hassid
May 1, 1985·Hypertension·R W AlexanderS E Rittenhouse
Jun 1, 1985·Molecular and Cellular Endocrinology·P EnyediA Spät
Mar 1, 1985·Endocrinology·M E ElliottT L Goodfriend
Jun 1, 1984·The Biochemical Journal·M J Berridge
Sep 17, 1984·Biochemical and Biophysical Research Communications·L BraleyG Williams
Jan 1, 1982·The Journal of Membrane Biology·A B BorleJ H Anderson
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M E Elliott, T L Goodfriend
Jul 1, 1981·The American Journal of Physiology·B S Hanks, N L Stephens
Jun 1, 1988·Physical Review. B, Condensed Matter·I Lemahieu Motoko-Kwete
Jul 14, 2004·Biochemistry·Deborah K WestFrank Maley
Nov 7, 2007·Analytical Chemistry·Sonia TaktakLee Josephson
Dec 3, 2008·Cancer Research·Takahiro IshiguroHisafumi Yamada-Okabe

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Citations

Dec 3, 1990·Molecular and Cellular Endocrinology·R E Kramer
Apr 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·M E ElliottT L Goodfriend
Mar 15, 2016·Frontiers in Endocrinology·András SpätGergő Szanda
Mar 27, 2004·Physiological Reviews·András Spät, László Hunyady
Jan 1, 1992·The American Journal of Physiology·W WangE G Schneider
Mar 1, 1991·Biochemical Pharmacology·M E ElliottT L Goodfriend

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