Angiotensin II-stimulated cortisol secretion is mediated by phospholipase D

Molecular and Cellular Endocrinology
Miriam RábanoMiguel Trueba

Abstract

Angiotensin II (Ang-II) regulates a variety of cellular functions including cortisol secretion. In the present report, we demonstrate that Ang-II activates phospholipase D (PLD) in zona fasciculata (ZF) cells of bovine adrenal glands, and that this effect is associated to the stimulation of cortisol secretion by this hormone. PLD activation was dependent upon extracellular Ca2+, and was blocked by inhibition of protein kinase C (PKC). Using the reverse transcription-polymerase chain reaction technique, we demonstrated that ZF cells express both PLD-1 and PLD-2 isozymes. Primary alcohols, which attenuate the formation of phosphatidate (the product of PLD), and cell-permeable ceramides, which inhibit PLD potently, blocked Ang-II-stimulated cortisol secretion. Furthermore, propranolol or chlorpromazine, which are potent inhibitors of phosphatidate phosphohydrolase (PAP) (the enzyme that produces diacylglycerol from phosphatidate), also blocked cortisol secretion. These data suggest that the PLD/PAP pathway plays an important role in the regulation of cortisol secretion by Ang-II in ZF cells.

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Citations

Feb 9, 2010·Lipids in Health and Disease·Lide AranaAntonio Gómez-Muñoz
Nov 22, 2014·The Journal of Endocrinology·F McManusE M Freel
Mar 3, 2010·Progress in Lipid Research·Patricia GangoitiAntonio Gómez-Muñoz
Apr 20, 2012·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Federico VeraCarlos Daniel Antenucci
Oct 12, 2013·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Ramiro OvejeroPablo Carmanchahi
Oct 16, 2007·Biochimica Et Biophysica Acta·Yasuaki HashimotoHirofumi Kai
Feb 18, 2016·The Journal of Endocrinology·Wendy B Bollag
Jan 23, 2017·General and Comparative Endocrinology·Federico VeraC Daniel Antenucci
Mar 24, 2006·Journal of Lipid Research·Leyre BrizuelaAntonio Gómez-Muñoz
Oct 13, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Joaquin Benitez-RajalMichael G Thompson

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