Angiotensin II stimulates activation of Fos-regulating kinase and c-Jun NH2-terminal kinase in neuronal cultures from rat brain

Endocrinology
X C HuangC Sumners

Abstract

c-Fos/c-Jun dimers (activating protein-1 transcription factor) are involved in the modulatory actions of angiotensin II (Ang II) on brain norepinephrine neurons, effects mediated via Ang II type 1 (AT1) receptors. The transcriptional activities of c-Fos and c-Jun can be augmented by Fos-regulating kinase (FRK) and c-Jun NH2-terminal kinase (JNK), respectively. In this study, we investigated the effects of Ang II on FRK and JNK activities in neurons cultured from newborn rat hypothalamus and brain stem, which include a population of catecholaminergic cells containing AT1 receptors. Ang II caused time-dependent increases in the activation of FRK and JNK, effects completely inhibited by the AT1 receptor antagonist losartan but not by the Ang II type 2 (AT2) receptor blocker PD123,319. The stimulation of FRK activity by Ang II was abolished by the protein kinase C (PKC) inhibitor GF109203X or the calcium chelator BAPTA, but not by inhibition of calmodulin or calcium/calmodulin-dependent protein kinase II. However, the activation of JNK by Ang II was not dependent on PKC or another calcium-dependent mechanism. These data demonstrate that Ang II stimulates activation of FRK and JNK in neuronal cells, actions that may contribute to th...Continue Reading

Citations

Sep 1, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Irving H ZuckerLie Gao
Dec 21, 2010·BMC Systems Biology·Gregory M MillerRajanikanth Vadigepalli
Jul 20, 2004·Current Hypertension Reports·Christa Thöne-ReinekeThomas Unger
Jan 8, 1999·Regulatory Peptides·M I Phillips, C Sumners
Apr 13, 2010·Progress in Retinal and Eye Research·Erica L FletcherJennifer L Wilkinson-Berka
May 16, 2002·Clinical and Experimental Pharmacology & Physiology·Colin SumnersMingyan Zhu
Aug 28, 2003·Journal of Cellular Physiology·Antonella MuscellaSanto Marsigliante
Mar 7, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·J CulmanT Unger
May 13, 1999·Molecular Neurobiology·E M RichardsC Sumners
Mar 3, 2007·Experimental Physiology·Derek DanielsSteven J Fluharty
Oct 23, 2015·PLoS Computational Biology·Hirenkumar K MakadiaRajanikanth Vadigepalli
Aug 27, 2005·Endocrinology·Derek DanielsSteven J Fluharty
May 29, 2003·British Journal of Pharmacology·Shereeni J Veerasingham, Mohan K Raizada
Jun 13, 2001·American Journal of Physiology. Cell Physiology·S J PanC H Gelband
May 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melissa A Fleegal, Colin Sumners
Feb 13, 2017·Pflügers Archiv : European journal of physiology·Anna HammerRalf A Linker
May 17, 2003·Archives of Oral Biology·Minako AbeTakashi Suzuki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.