Angiotensin II stimulates water and NaCl intake through separate cell signalling pathways in rats.

Experimental Physiology
Derek DanielsS J Fluharty

Abstract

Angiotensin II (AngII) stimulation of water and NaCl intake is a classic model of the behavioural effects of hormones. In vitro studies indicate that the AngII type 1 (AT(1)) receptor stimulates intracellular pathways that include protein kinase C (PKC) and mitogen-activated protein (MAP) kinase activation. Previous studies support the hypotheses that PKC is involved in AngII-induced water, but not NaCl intake and that MAP kinase plays a role in NaCl consumption, but not water intake, after injection of AngII. The present experiments test these hypotheses in rats using central injections of AngII in the presence or absence of a PKC inhibitor or a MAP kinase inhibitor. Pretreatment with the PKC inhibitor chelerythrine attenuated AngII-induced water intake, but NaCl intake was unaffected. In contrast, pretreatment with U0126, a MAP kinase inhibitor, had no effect on AngII-induced water intake, but attenuated NaCl intake. These data support the working hypotheses and significantly extend our earlier findings and those of others. Perhaps more importantly, these experiments demonstrate the remarkable diversity of peptide receptor systems and add support for the surprising finding that intracellular signalling pathways can have diver...Continue Reading

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Citations

Jun 7, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Etienne BérardAmandine Rubio
Apr 13, 2010·Physiology & Behavior·Annette D de KloetStephen C Woods
Mar 17, 2010·Physiology & Behavior·Laurival A De LucaJosé V Menani
Apr 16, 2015·Frontiers in Systems Neuroscience·Justin A SmithEric G Krause
Dec 7, 2018·The Journal of Endocrinology·G Almeida-PereiraJ Antunes-Rodrigues
Jan 10, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jose V MenaniAlan Kim Johnson
Jun 27, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeffrey P CobleCurt D Sigmund
Jun 18, 2020·The Journal of Biological Chemistry·Shalinee JhaPeter Macheroux
Oct 8, 2013·Journal of Hypertension·Jens Jordan
Feb 14, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jun LiuKathryn Sandberg
Dec 19, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeffrey P CobleCurt D Sigmund
Jun 27, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Michele IovinoVincenzo Triggiani

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