Angiotensin II type 1 receptor antagonists in animal models of vascular, cardiac, metabolic and renal disease

Pharmacology & Therapeutics
Martin C MichelYong Huo

Abstract

We have reviewed the effects of angiotensin II type 1 receptor antagonists (ARBs) in various animal models of hypertension, atherosclerosis, cardiac function, hypertrophy and fibrosis, glucose and lipid metabolism, and renal function and morphology. Those of azilsartan and telmisartan have been included comprehensively whereas those of other ARBs have been included systematically but without intention of completeness. ARBs as a class lower blood pressure in established hypertension and prevent hypertension development in all applicable animal models except those with a markedly suppressed renin-angiotensin system; blood pressure lowering even persists for a considerable time after discontinuation of treatment. This translates into a reduced mortality, particularly in models exhibiting marked hypertension. The retrieved data on vascular, cardiac and renal function and morphology as well as on glucose and lipid metabolism are discussed to address three main questions: 1. Can ARB effects on blood vessels, heart, kidney and metabolic function be explained by blood pressure lowering alone or are they additionally directly related to blockade of the renin-angiotensin system? 2. Are they shared by other inhibitors of the renin-angiote...Continue Reading

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Citations

Aug 19, 2016·Frontiers in Pharmacology·Georgios GeorgiopoulosDimitrios Tousoulis
Sep 11, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Amal M MahfozAfaf A Shoka
Feb 23, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Sudeep P PushpakomMunir Pirmohamed
Apr 11, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Luciana M A BorémSergio H S Santos
Jul 5, 2018·Journal of Cellular and Molecular Medicine·Seth J CoreyRegina M Day
Jul 27, 2017·Journal of the American Heart Association·Tao XuYangmei Chen
Jun 20, 2017·Pharmacological Reviews·Yuri K Peterson, Louis M Luttrell
Jan 13, 2018·Molecular Pharmacology·Martin C Michel, Steven J Charlton
Jul 12, 2017·Cell Discovery·Qiang LiuChengyu Jiang
Aug 7, 2019·Plastic and Reconstructive Surgery·Amanda MurphyMichael Bezuhly
Dec 29, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Liyan BaiMyung Ho Jeong
Mar 19, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gianna HuberWalter Raasch
Jun 12, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Laura BeckmannWalter Raasch
Jul 3, 2021·Pharmaceuticals·Mohamed M El-KadyMaha Saber-Ayad
Jul 10, 2021·Experimental Cell Research·Yuting YangJuxiang Li
Jun 5, 2017·Advanced Drug Delivery Reviews·Stefania CannitoMaurizio Parola

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