Angiotensin II type 1 receptor (AT-1R) expression correlates with VEGF-A and VEGF-D expression in invasive ductal breast cancer.

Pathology Oncology Research : POR
Aleksandra JethonMarzena Podhorska-Okolow

Abstract

Recent studies point to the involvement of angiotensin II (Ang II) receptor type 1 (AT-1R) on processes of metastasing, stimulation of invasiveness and angiogenesis in tumours. In this study, the correlation between intensity of AT-1R expression and expression of lymph- and angiogenesis markers in invasive ductal breast cancers (IDC) was examined. Immunohistochemical studies (IHC) were performed on archival material of 102 IDC cases. Only 28 (27.5%) cases manifested low AT-1R expression while 74 (72.5%) cases demonstrated a moderate or pronounced AT-1R expression. Expression intensity of AT-1R was found to correlate with expressions of VEGF-A (r = 0.26; p = 0.008) and VEGF-D (r = 0.24; p = 0.015). Out of the examined markers of angiogenesis and lymphangiogenesis only the pronounced expression of VEGF-C was found to correlate with patient poor clinical outcome (p = 0.009). The positive correlation between AT-1R and VEGF-A and VEGF-D could point to stimulatory action of Ang II on their expression what might result in augmented lymph- and angiogenesis in IDC.

References

Jan 1, 1994·The Journal of Urology·D A GoldfarbA C Novick
Jan 1, 1997·British Journal of Cancer·E R InwangG P Vinson
Sep 11, 2001·Experimental Nephrology·F BonnetM E Cooper
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Yusuke SuzukiJesus Egido
Mar 10, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshio ImanishiIchiro Nishio
Apr 9, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takayasu SuganumaFumitaka Kikkawa
Jul 27, 2005·Peptides·U M SteckelingsTh Unger
Aug 3, 2005·Trends in Endocrinology and Metabolism : TEM·Frédérique Deshayes, Clara Nahmias
Sep 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Angela M González-Zuloeta LaddCornelia van Duijn
Jun 7, 2006·British Journal of Cancer·M TahmasebiG P Vinson
Jul 11, 2006·Breast Cancer Research and Treatment·A M González-Zuloeta LaddC M van Duijn
Sep 7, 2006·Endocrine-related Cancer·J R PuddefootG P Vinson
Nov 30, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E MylonaL Nakopoulou
Feb 24, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Nozomi ImaiSatoshi Umemura
Apr 20, 2007·Cancer Letters·Daisy W J van der SchaftArjan W Griffioen
Apr 25, 2007·Breast Cancer Research and Treatment·A M González-Zuloeta LaddC M van Duijn
Jun 15, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A M González-Zuloeta LaddC M van Duijn
Feb 27, 2009·American Journal of Physiology. Renal Physiology·Tanya M GwathmeyMark C Chappell
Jun 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Daniel R RhodesArul M Chinnaiyan
Sep 19, 2009·Cellular and Molecular Life Sciences : CMLS·Daniel W LambertAnthony J Turner
Aug 3, 2010·Folia Histochemica Et Cytobiologica·Agnieszka GomulkiewiczPiotr Dziegiel
Jan 5, 2011·Breast Cancer Research : BCR·Jack Cuzick
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Apr 14, 2011·Clinical Science·Lauren M WillisSusan C Fagan

❮ Previous
Next ❯

Citations

Nov 20, 2012·Clinical Science·Ibrahim C Haznedaroglu, Yavuz Beyazit
Feb 16, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Oscar ArrietaArmando Gamboa-Domínguez
Jan 8, 2014·Experimental and Therapeutic Medicine·Yun-Fei DuanFeng Zhang
Jun 7, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Derick Okwan-DuoduRoberto Diaz
Mar 7, 2021·Cells·Maksymilian ZiajaAgnieszka Wanda Piastowska-Ciesielska
Mar 24, 2021·Molecular and Cellular Endocrinology·Flávia Sardela de MirandaNaima Moustaid-Moussa

❮ Previous
Next ❯

Software Mentioned

Prism

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.