Angiotensin-II type 1 receptor (AT1R) and alpha-1D adrenoceptor form a heterodimer during pregnancy-induced hypertension

Autonomic & Autacoid Pharmacology
M de Lourdes González-HernándezP López-Sánchez

Abstract

Pregnancy courses with low response to angiotensin II and adrenergic agonists. In preeclampsia, both effects are reverted. It is known that angiotensin II regulates adrenergic system. It is not known, however, the interaction between both systems receptors. Our aim was to study if AT(1)R and alpha1D adrenoceptor heterodimerize in preeclampsia. We used subrenal aorctic coarctation in pregnant rats. Aortic tissues were prepared for confocal imaging and coimmunoprecipitated for alpha1D and AT(1) receptors. We found that AT(1)R and alpha1D adrenoceptor heterodimerize in both, healthy and preeclamptic groups. In healthy pregnant rats, heterodimer is barely detected. In preeclamptic rats however, we found higher heterodimerization. These results suggest that AT(1)R and alpha1D -adrenoceptor may form heterodimers, and may play a role in preeclampsia.

References

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Citations

Sep 29, 2011·Autonomic & Autacoid Pharmacology·M L Lázaro-SuárezR Villalobos-Molina
Mar 25, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Caroline SunggipMotohiro Nishida
Jun 27, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Takanobu TakezakoKoichi Node
Jun 7, 2018·Physiological Reviews·Steven J ForresterSatoru Eguchi
Oct 12, 2018·The Journal of Physiology·E N Bardsley, D J Paterson
May 28, 2013·Cardiology in Review·Timothy J VittorioConstantine E Kosmas
Aug 28, 2020·Frontiers in Pharmacology·Natalia L Rukavina MikusicMariela M Gironacci
Oct 24, 2014·American Journal of Physiology. Renal Physiology·Riley Charles EnnisVan Anthony M Villar
Mar 21, 2020·Journal of Hypertension·Jessica E RodríguezItzell A Gallardo-Ortíz

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