Angiotensin II type 1 receptor expression in human pancreatic cancer and growth inhibition by angiotensin II type 1 receptor antagonist

FEBS Letters
Y FujimotoK Chayama

Abstract

We investigated the expression of angiotensin II type 1 receptor (AT1) in pancreatic cancer. Both AT1 mRNA and protein were expressed in human pancreatic cancer tissues and cell lines. Binding assays showed that pancreatic cancer cells have specific binding sites for angiotensin II and that binding could be eliminated by treatment with a selective AT1 antagonist in a dose-dependent fashion. Surprisingly, the growth of cancer cells was significantly suppressed by treatment with antagonist, also in a dose-dependent manner. These observations suggest AT1 plays an important role in pancreatic cancer growth. Furthermore, ligand-induced inhibition of AT1 may be a useful therapeutic strategy.

References

Nov 30, 1989·Biochemical and Biophysical Research Communications·A T ChiuA L Johnson
Aug 30, 1989·Biochemical and Biophysical Research Communications·S WhitebreadM de Gasparo
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·M NakajimaV J Dzau
Jan 1, 1995·The Journal of Clinical Investigation·Y NioM Inada
Jan 1, 1994·The Journal of Urology·D A GoldfarbA C Novick
Dec 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·M K ReddyA Molteni
Jan 1, 1997·British Journal of Cancer·E R InwangG P Vinson

❮ Previous
Next ❯

Citations

Apr 10, 2012·Archives of Gynecology and Obstetrics·Qing YangRina Sa
May 15, 2012·Pathology Oncology Research : POR·Aleksandra JethonMarzena Podhorska-Okolow
Oct 23, 2010·Nature Reviews. Cancer·Amee J GeorgeRoss D Hannan
Jun 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Daniel R RhodesArul M Chinnaiyan
Mar 23, 2007·Journal of Gastroenterology and Hepatology·Jaclyn H NeoChristopher Christophi
Apr 9, 2005·Journal of Inflammation·Gary Robert Smith, Sotiris Missailidis
Feb 11, 2012·Molecular Endocrinology·Rekha YesudasThomas Thekkumkara
Dec 20, 2011·Endocrine-related Cancer·Gavin P VinsonJohn R Puddefoot
Mar 1, 2006·Expert Opinion on Biological Therapy·Kazuhiko InoFumitaka Kikkawa
Feb 2, 2016·Homeopathy : the Journal of the Faculty of Homeopathy·Lucas Ferrari de AndradeEdvaldo da Silva Trindade
Jan 22, 2013·Néphrologie & thérapeutique·Thibault Dolley-HitzeCécile Vigneau
Feb 1, 2011·Pharmacology & Therapeutics·Christos VaklavasApostolia Maria Tsimberidou
Apr 13, 2010·Physiology & Behavior·Annette D de KloetStephen C Woods
Apr 29, 2015·International Heart Journal·Takehiro KamoIssei Komuro
Jun 3, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Akira MiyajimaMototsugu Oya
Oct 1, 2008·Molecular and Cellular Endocrinology·L ChowS N S Louis
Dec 23, 2004·Chinese Journal of Digestive Diseases·Hua JiangYan Fang Gong
May 3, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hidenori ItabashiTomoyuki Masuda
Jan 11, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Hiroji UemuraYoshinobu Kubota
Aug 20, 2011·Alimentary Pharmacology & Therapeutics·J R A SkipworthH E Montgomery
Aug 6, 2010·The Prostate·Simon N S LouisWilliam J Louis
Mar 24, 2016·Cancer Letters·Ying LiuTian-Rui Xu
Feb 7, 2006·Nuclear Medicine and Biology·Tamas G ZoberZsolt Szabo
Oct 18, 2005·Molecular and Cellular Endocrinology·Katarina TybitanclovaStefan Zorad
Aug 3, 2005·Trends in Endocrinology and Metabolism : TEM·Frédérique Deshayes, Clara Nahmias
May 20, 2015·European Journal of Pharmacology·Anukriti SinghBushra Ateeq
Apr 15, 2011·Journal of Pregnancy·Mitsuko FuruyaIchiro Aoki
Oct 12, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Soha NamaziRita Arabsolghar
Feb 16, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Oscar ArrietaArmando Gamboa-Domínguez
May 29, 2004·American Journal of Obstetrics and Gynecology·Fumitaka KikkawaShigehiko Mizutani
Jan 17, 2015·International Journal of Colorectal Disease·W Kurtis Childers
Jun 25, 2013·Cancer Biology & Therapy·Shu Wen WenChristopher Christophi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.