Angiotensin II type 1 receptor gene polymorphism is associated with increase of left ventricular mass but not with hypertension

American Journal of Hypertension
S TakamiToshio Ogihara

Abstract

A genetic epidemiologic approach is useful to elucidate the genes responsible for hypertension. Genetic analyses of the components of the renin-angiotensin system have succeeded in showing an association between their polymorphism and hypertension. Recently, two types of angiotensin II receptor were cloned and characterized. To examine the genetic contribution of angiotensin II type 1 receptor (AT1) and type 2 receptor (AT2) genes in human essential hypertension, a case-control study was performed in Japanese subjects. The study comprised 321 subjects with hypertension who satisfied the criteria for essential hypertension, together with 215 age and sex matched controls. The significance of the differences in genotype distribution between hypertensive and normotensive subjects was examined by chi2 analysis. Neither AT1 nor AT2 gene variants were associated with human essential hypertension in the Japanese subjects. However, the AT1 receptor gene polymorphism was associated with left ventricular mass index in normotensive subjects. The study results suggest that gene polymorphisms of both angiotensin II receptors are not directly involved in the increase of genetic risk for hypertension, but that the AT1 receptor gene might contr...Continue Reading

Citations

Feb 24, 2001·Current Opinion in Nephrology and Hypertension·J A DuncanJ A Miller
Apr 28, 2001·Japanese Heart Journal·S AokiT Katagiri
Aug 20, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jing-Ji JinTetsuro Miki
Oct 20, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ken SugimotoToshio Ogihara
Mar 10, 2005·Journal of Clinical Laboratory Analysis·Maja ZivkovićDragan Alavantić
Oct 20, 2004·Circulation·Tatiana KuznetsovaUNKNOWN European Project On Genes in Hypertension (EPOGH) Investigators
Nov 12, 2005·Critical Reviews in Clinical Laboratory Sciences·Miles D ThompsonDavid E C Cole
Jul 22, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Amy K MottlKari E North
Dec 10, 2009·Medicine and Science in Sports and Exercise·Michele Di MauroSabina Gallina
Oct 27, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Akira FunadaMasakazu Yamagishi
Jan 15, 2011·Molecular and Cellular Biochemistry·Wael FarragManal Abdallah
Apr 18, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Djabaria Naïma MeroufelThierry Brousseau
Jul 18, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Hyung-Ki KimHak-Jae Kim
May 9, 2019·International Ophthalmology·Aikaterini ChristodoulouGeorgios Kitsos
Aug 21, 2001·Hypertension Research : Official Journal of the Japanese Society of Hypertension·T KatsuyaT Ogihara
Feb 9, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Ehsan BahramaliMassoumeh Shafiei
Aug 1, 2000·Indian Journal of Clinical Biochemistry : IJCB·T F AshavaidJ J Dalal
Sep 24, 1999·Current Opinion in Nephrology and Hypertension·T H Le, T M Coffman
Mar 23, 2002·Journal of Hypertension·Robert H Fagard, Tatiana Kuznetsova
Jul 12, 2001·Japanese Circulation Journal·S AokiT Katagiri
Mar 12, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Koh OnoNaoharu Iwai
Feb 24, 2004·Molecular Pharmacology·Jakob Lerche HansenDavid M Weiner
Oct 3, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ying LiuChangchun Qiu
Jan 11, 2005·Experimental Physiology·Bruno Baudin
Aug 24, 2011·Journal of Inflammation·Manal F ElshamaaDalia A Abd-El Haleem
Mar 12, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masahiro KikuyaMitsunobu Matsubara
Jan 28, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Scott M WilliamsJason H Moore
May 11, 2013·Molecular Biology Reports·Negar FirouzabadiMassoumeh Shafiei
Sep 10, 2003·Hypertension·Thu H LeThomas M Coffman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.