Angiotensin II type 1 receptor has impact on murine placentation

Placenta
Thomas WaltherHolger Stepan

Abstract

Impaired placentation is a key step in the pathogenesis of important pregnancy disorders such as preeclampsia and fetal growth restriction. A role of angiotensin II in placental development can be assumed from the expression of angiotensin receptors on trophoblast from the earliest stages of pregnancy. To understand the role of angiotensin II type 1 (AT1) receptors in placental development, we investigated placentae of AT1a-deficient mice early in pregnancy (day 13 postconception). The number of alive newborns was significantly reduced in AT1a-deficient mice caused by placental malformations in 30% of all utero-placental units. Importantly, no embryonic structure was observable within the uterine segments harboring the malformed placentae. Immunohistochemistry with an antibody against murine betahCG-equivalent stained homogeneously in almost all cells in the altered placentae indicating still an endocrine-active trophoblast. However, the typical structure of the murine wild-type placenta in spongiotrophoblast, giant cells, and labyrinth was abolished in malformed placental tissue deficient in the AT1a receptor. Recent epidemiological studies revealed the detrimental effect of an AT1 blockade for fetal outcome due to renal malfo...Continue Reading

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Citations

May 6, 2011·Journal of Molecular Histology·Shin MatsubaraAtsushi P Kimura
Oct 30, 2013·Clinical and Experimental Pharmacology & Physiology·Eugenie R LumbersKaren J Gibson
May 23, 2015·International Journal of Endocrinology·Norikazu UekiKeizo Kanasaki
Nov 12, 2016·Journal of the American Society of Hypertension : JASH·Lise H NielsenBoye L Jensen
Aug 27, 2010·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Luke C Carey, James C Rose
Jun 18, 2020·Reproductive Sciences·Eugene D Albrecht, Gerald J Pepe
Jan 13, 2018·Reproductive Biology and Endocrinology : RB&E·Elham GhadhanfarMaie Al-Bader
Feb 12, 2021·Early Human Development·Stefano ForestieriVassilios Fanos

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