Angiotensin II type 1 receptor-mediated augmentation of urinary excretion of endogenous angiotensin II in Val5-angiotensin II-infused rats.

Hypertension
Weijian ShaoL Gabriel Navar

Abstract

Rats infused chronically with Val(5)-Angiotensin (Ang) II exhibit increased urinary excretion of endogenous Ile(5)-Ang II by the 12th day of infusion, suggesting the stimulation of endogenous Ang II formation by Val(5)-Ang II infusion. The present study determined the time course of increased urinary Ang II excretion and the effects of Ang II type 1 receptor blockade (candesartan, 2 mg/kg per day) on the urinary excretion rates of Ile(5)-Ang II in Val(5)-Ang II-infused (80 ng/min) rats. Ile(5)-Ang II was separated from Val(5)-Ang II by high-performance liquid chromatography and measured by radioimmunoassay. Systolic blood pressure increased progressively (215+/-2 mm Hg) in Val(5)-Ang II-infused rats (n=5), whereas the candesartan-treated group (n=6) remained normotensive (124+/-3 mm Hg). Candesartan treatment significantly increased the level of plasma Ile(5)-Ang II (24.0+/-7.6 versus 156.9+/-24.6 fmol/mL; P<0.01); in contrast, there was a markedly lower intrarenal Ile(5)-Ang II content (357.9+/-76.6 versus 21.1+/-2.8 fmol/g; P<0.01). Urinary Ile(5)-Ang II excretion rates were elevated by day 9 (2185.7+/-283.2 fmol/24 hours) in Val(5)-Ang II-infused rats but not in candesartan-treated rats (740.6+/-110.3 fmol/24 hours). Thus, A...Continue Reading

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Citations

Sep 9, 2011·American Journal of Physiology. Renal Physiology·Lucienne S LaraMinolfa C Prieto
Jan 11, 2013·American Journal of Physiology. Renal Physiology·Weijian ShaoL Gabriel Navar
Feb 2, 2011·Hypertension·L Gabriel NavarRomer A Gonzalez-Villalobos
Sep 25, 2014·The American Journal of the Medical Sciences·Alexis A GonzalezMinolfa C Prieto
Jul 16, 2014·Kidney International Supplements·L Gabriel Navar
Feb 23, 2011·Current Opinion in Pharmacology·L Gabriel NavarHiroyuki Kobori
May 24, 2013·Journal of Pharmacological Sciences·Keisuke OhnishiAkira Nishiyama
Mar 18, 2015·Therapeutic Advances in Cardiovascular Disease·Alexis A Gonzalez, Minolfa C Prieto
May 20, 2015·Therapeutic Advances in Cardiovascular Disease·Ryousuke SatouL Gabriel Navar
Aug 25, 2010·Hypertension·Mieke van den HeuvelA H Jan Danser
Jan 1, 2014·Current Opinion in Nephrology and Hypertension·Kenneth E BernsteinRomer A Gonzalez-Villalobos
Nov 27, 2015·American Journal of Physiology. Renal Physiology·Alexis A GonzalezMinolfa C Prieto
Sep 26, 2019·Frontiers in Endocrinology·Eugenie R LumbersKirsty G Pringle
Nov 6, 2014·Clinical and Experimental Pharmacology & Physiology·Alexis A Gonzalez, Minolfa C Prieto

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