Angiotensin II type 2 receptor agonist Compound 21 attenuates pulmonary inflammation in a model of acute lung injury

Journal of Inflammation Research
Mario MenkDavid Schwaiberger

Abstract

Although the role of the angiotensin II type 2 (AT2) receptor in acute lung injury is not yet completely understood, a protective role of this receptor subtype has been suggested. We hypothesized that, in a rodent model of acute lung injury, stimulation of the AT2 receptor with the direct agonist Compound 21 (C21) might have a beneficial effect on pulmonary inflammation and might improve pulmonary gas exchange. Male adult rats were divided into a treatment group that received pulmonary lavage followed by mechanical ventilation (LAV, n=9), a group receiving pulmonary lavage, mechanical ventilation, and direct stimulation of the AT2 receptor with C21 (LAV+C21, n=9), and a control group that received mechanical ventilation only (control, n=9). Arterial blood gas analysis was performed every 30 min throughout the 240-min observation period. Lung tissue and plasma samples were obtained at 240 min after the start of mechanical ventilation. Protein content and surface activity of bronchoalveolar lavage fluid were assessed and the wet/dry-weight ratio of lungs was determined. Transcriptional and translational regulation of pro- and antiinflammatory cytokines IL-1β, tumor necrosis factor-alpha, IL-6, IL-10, and IL-4 was determined in lu...Continue Reading

Citations

Apr 9, 2019·Acta Physiologica·Colin SumnersUlrike Muscha Steckelings
Jun 23, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Ioannis Akoumianakis, Theodosios Filippatos
Sep 6, 2019·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Renata Calciolari RossiThais Mauad
Nov 20, 2020·Clinical Science·U Muscha Steckelings, Colin Sumners
Jul 9, 2021·British Journal of Pharmacology·Juliana Fabiana GregórioGiselle Santos Magalhães

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Methods Mentioned

BETA
lavage
bronchoalveolar lavage
fluorescence-activated cell sorting

Software Mentioned

GraphPad PRISM
SPSS
SPSS Statistics
ImageJ

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