Angiotensin II type 2 receptor signaling affects dopamine levels in the brain and prevents binge eating disorder

Journal of the Renin-angiotensin-aldosterone System : JRAAS
Hirotomo NakaokaMasatsugu Horiuchi

Abstract

Binge eating disorder (BED) is associated with dopaminergic activation as food reward, resulting in metabolism-related disorders. Stimulation of angiotensin type 2 (AT2) receptor is reported to inhibit dopamine synthesis. We investigated the possible roles of AT2 receptor-mediated dopamine regulation in the pathogenesis of BED. Male C57BL/6 mice, type 2 diabetic (KKAy) mice and AT2 receptor-null (AT2KO) mice at eight weeks old were treated with AT2 receptor agonist, compound 21 (C21) or saline for two weeks. Mice were subjected to fasting for two days followed by re-feeding for seven days. Treatment with C21 attenuated the rebound proportion of body weight, food intake and water intake in KKAy mice, but not in C57BL/6 and AT2KO mice. Dopamine concentration in the striatum was further increased by fasting in KKAy and AT2KO mice. Administration of C21 significantly attenuated this fasting-induced increase in dopamine level only in KKAy mice. Dopamine receptor D1, D2 expression in the substantia nigra were markedly lower in KKAy mice compared with C57BL/6 mice, while administration of C21 increased their expression in KKAy mice. Our study suggests that AT2 receptor stimulation may be a new therapeutic approach to improve eating di...Continue Reading

References

May 10, 2000·Nature Genetics·M S SzczypkaR D Palmiter
Feb 24, 2001·Lancet·G J WangJ S Fowler
Oct 22, 2002·Expert Opinion on Therapeutic Targets·Gene-Jack WangJoanna S Fowler
Mar 6, 2004·Eating Behaviors·J KenardyM Dalton
Sep 10, 2004·The European Journal of Neuroscience·J Rodriguez-PallaresJ L Labandeira-Garcia
Sep 22, 2006·Nature·G J MortonM W Schwartz
Feb 12, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Caroline DavisJames L Kennedy
May 24, 2008·Neurobiology of Disease·J Rodriguez-PallaresJ L Labandeira-Garcia
Apr 27, 2010·Pharmacology, Biochemistry, and Behavior·Nicholas T Bello, Andras Hajnal
Apr 30, 2010·The American Journal of Clinical Nutrition·James I HudsonHarrison G Pope
May 12, 2010·Archives of Neurology·Daniel WeintraubAnthony E Lang
Oct 6, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fei JingMasatsugu Horiuchi
Jul 28, 2012·Current Hypertension Reports·Sébastien FoulquierThomas Unger
Sep 29, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·N D VolkowR D Baler
Nov 21, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Michael BaderU Muscha Steckelings
Jan 22, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·K SchagK E Giel

❮ Previous
Next ❯

Citations

Jan 16, 2016·Oxidative Medicine and Cellular Longevity·Hugo Juárez OlguínGerardo Barragán Mejía
Jun 14, 2017·Medicinal Research Reviews·Mathias HallbergAnders Hallberg
Feb 14, 2021·Biomolecules·Alejandro Olivares-HernándezJosé Pablo Miramontes-González

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.