Angiotensin II type I receptor blockade attenuates reflex cutaneous vasoconstriction in aged but not young skin

American Journal of Physiology. Heart and Circulatory Physiology
James A Lang, Kelsey E Kolb

Abstract

Stimulation of angiotensin II type I receptors (AT1R) elicits vasoconstriction (VC) that may be occurring through the activation of a pathogenic vascular pathway such as Rho kinase (ROCK). We hypothesize that reflex cutaneous VC to whole body cooling (mean skin temperature = 30.5°C) in older humans relies in part on AT1R activation, which may explain greater ROCK activity attendant with aging. Two microdialysis (MD) fibers were placed in the forearm skin of 10 young (Y; 24 ± 1 yr) and 10 older (O; 70 ± 2 yr) individuals for infusion of 1) lactated Ringer's solution (switched to fasudil, a ROCK antagonist, after cooling); and 2) AT1R blockade with losartan. Laser Doppler flux (LDF) was measured over each MD site and cutaneous vascular conductance (CVC) was calculated (CVC = LDF/mean arterial pressure) and expressed as percent change from baseline (%ΔCVCBASELINE). In older individuals the VC response to whole body cooling was blunted (Y = -34 ± 2, O = -17 ± 3%ΔCVC) and was further attenuated at the losartan site (Y = -34 ± 3, O = -9 ± 3%ΔCVC; P < 0.05). The VC response to an exogenous 10-μM dose of angiotensin II (Y = -27 ± 3, O = -42 ± 5%ΔCVC) was completely blocked in sites pretreated with losartan or with fasudil. These data s...Continue Reading

References

Feb 1, 1994·The Journal of Clinical Investigation·B ClemsonR Zelis
Feb 1, 1996·Journal of Applied Physiology·W L Kenney, C G Armstrong
Jul 20, 1999·Journal of Applied Physiology·N Charkoudian, J M Johnson
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M A ChotaniN A Flavahan
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·D P StephensJ M Johnson
Feb 28, 2004·Experimental Dermatology·U Muscha SteckelingsMetin Artuc
Jun 8, 2004·The Journal of Physiology·Caitlin S Thompson, W Larry Kenney
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Trinity J BivalacquaPhilip J Kadowitz
Jan 8, 2005·Stroke; a Journal of Cerebral Circulation·Sean P DidionFrank M Faraci
Jan 22, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Caitlin S ThompsonW Larry Kenney
Mar 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·S R BaileyN A Flavahan
Sep 6, 2005·Stroke; a Journal of Cerebral Circulation·Yoshiyuki RikitakeJames K Liao
Jan 2, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David W Degroot, W Larry Kenney
Apr 10, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Caitlin S Thompson-TorgersonW Larry Kenney
Nov 13, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Julian M StewartMarvin S Medow
May 13, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Julian M StewartMarvin S Medow
Feb 7, 2009·Journal of Applied Physiology·Gary J HodgesJohn M Johnson
Feb 7, 2009·The Journal of Clinical Investigation·Ariela BenigniGiuseppe Remuzzi
Jun 6, 2009·The Journal of Physiology·James A LangW Larry Kenney
Aug 21, 2009·American Journal of Physiology. Cell Physiology·Jeremy BregeonMalvyne Rolli-Derkinderen
Sep 1, 2009·American Journal of Physiology. Heart and Circulatory Physiology·James A LangW Larry Kenney
Sep 19, 2012·Clinical Science·Zachary Barrett-O'KeefeD Walter Wray
Mar 14, 2013·Microvascular Research·Caroline J SmithLacy M Alexander
Aug 8, 2013·Journal of Cardiovascular Pharmacology·Jianjian Shi, Lei Wei

❮ Previous
Next ❯

Citations

Mar 16, 2017·Experimental Physiology·James A LangKevin A Smaller
Nov 25, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Naoto FujiiGlen P Kenny
Dec 1, 2018·American Journal of Physiology. Heart and Circulatory Physiology·James A Lang, Alex C Krajek
Mar 31, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Ryan McGinnGlen P Kenny
Nov 28, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Jahyun KimJames A Lang
Aug 15, 2015·Journal of Applied Physiology·Jody L GreaneyW Larry Kenney
Sep 22, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brendan D McNeelyGlen P Kenny
Mar 15, 2021·Mayo Clinic Proceedings·Mark A CappelDavid A Wetter
Sep 16, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michail E KeramidasOla Eiken

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
James A LangW Larry Kenney
American Journal of Physiology. Heart and Circulatory Physiology
Caitlin S Thompson-TorgersonW Larry Kenney
© 2021 Meta ULC. All rights reserved