PMID: 8971933Jan 1, 1996Paper

Angiotensin III and IV activation of the brain AT1 receptor subtype in cardiovascular function

Peptides
J W WrightJ W Harding

Abstract

The present investigation determined that native angiotensins II and III (ANG II and III) were equipotent as pressor agents when ICV infused in alert rats, whereas native angiotensin IV (ANG IV) was less potent. An analogue of each of these angiotensins was prepared with a hydroxyethylamine (HEA) amide bond replacement at the N-terminus, yielding additional resistance to degradation. These three angiotensin analogues, HEA-ANG II, HEA-ANG III, and HEA-ANG IV, were equivalent with respect to maximum elevation in pressor responses when ICV infused; and each evidenced significantly extended durations of effect compared with their respective native angiotensin. Comparing analogues, HEA-ANG II had a significantly longer effect compared with HEA-ANG III, and HEA-ANG IV, whereas the latter were equivalent. Pretreatment with the AT1 receptor subtype antagonist, Losartan (DuP753), blocked subsequent pressor responses to each of these analogues, suggesting that these responses were mediated by the AT1 receptor subtype. Pretreatment with the specific AT4 receptor subtype antagonist, Divalinal (HED 1291), failed to influence pressor responses induced by the subsequent infusion of these analogues. These results suggest an important role for ...Continue Reading

References

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Sep 1, 1992·Brain Research. Brain Research Reviews·J W Wright, J W Harding
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Citations

Apr 27, 2012·Pflügers Archiv : European journal of physiology·John W Wright, Joseph W Harding
Nov 25, 1997·Brain Research. Brain Research Reviews·J W Wright, J W Harding
Sep 12, 1998·Nature Medicine·Y KakinumaA Fukamizu
Jan 16, 2013·International Journal of Hypertension·Marie-Odile Guimond, Nicole Gallo-Payet
Jul 14, 2012·International Journal of Hypertension·John W WrightJoseph W Harding
Jul 23, 2011·Progress in Neurobiology·John W Wright, Joseph W Harding
Dec 2, 2008·CNS Neuroscience & Therapeutics·Dimitri De BundelYvette Michotte
Jul 29, 2011·The FEBS Journal·Subhash C Prajapati, Shyam S Chauhan
May 23, 2013·Peptides·Vudhya G Yugandhar, Michelle A Clark
Dec 3, 2014·Progress in Neurobiology·John W WrightJoseph W Harding
May 12, 2007·Regulatory Peptides·Vardan T Karamyan, Robert C Speth
Jun 20, 2006·Regulatory Peptides·Rajash K Handa
Dec 20, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Zhice XuJiaming Yao
May 27, 2010·Journal of Hypertension·Alain G Dupont, Sofie Brouwers
Aug 22, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anthony L AlbistonSiew Yeen Chai
Jan 14, 1999·Journal of Hypertension·J ZhuoF A Mendelsohn
Jun 3, 2018·Neurochemical Research·Ann Tenneil O'Connor, Michelle A Clark
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P D PottsR A Dampney

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