PMID: 6160349Jan 1, 1981Paper

Angiotensin-induced release of a prostacyclin-like substance from the lungs

Journal of Cardiovascular Pharmacology
G J Dusting

Abstract

Intravenous infusions of angiotensins I and II into anesthetized dogs caused release of a prostacyclin-like substance into arterial blood: prostacyclin (PGI2) was detected by direct bioassay on bovine coronary artery, rat stomach strip, and rat colon, all of which were treated with phenoxybenzamine, propranolol, and Sar1-Ile8-angiotensin II. This effect of angiotensin I, but not of angiotensin II, was abolished by captopril (1 mg/kg, i.v.), and the effect of angiotensin II was abolished by Sar1-Ala8-angiotensin II (0.5 micrograms/kg/min, i.v.). The PGI2-like substance disappeared during incubation of arterial blood for 6 min, and much less appeared in mixed venous blood withdrawn from the right atrium of pulmonary artery, indicating that it originates from the lungs. Neither arterial nor mixed venous blood contained measurable amounts of prostaglandin E2; infusions of noradrenaline did not release the PGI2-like substance. Release of the PGI2-like substance by angiotensin II was reduced after intravenous administration of indomethacin (2, 5, or 10 mg/kg), aspirin (100 mg/kg), aspirin (100 mg/kg), and meclofenamic acid (2 mg/kg), but was not completely eliminated by any of the above inhibitors. In indomethacin-treated dogs the re...Continue Reading

Citations

May 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·H JuanF Lembeck
Jun 1, 1987·Agents and Actions·G YilmazR K Türker
Jul 20, 1983·The American Journal of Cardiology·G J DustingT J Martin
Mar 12, 1981·European Journal of Pharmacology·G J DustingR D Nolan
Jan 27, 1988·European Journal of Pharmacology·C A GruetterD D Schoepp
Sep 1, 1983·Prostaglandins, Leukotrienes, and Medicine·Z S ErcanR K Türker
Jul 1, 1992·American Journal of Obstetrics and Gynecology·G SorokinJ H Lombard
May 1, 1983·Clinical and Experimental Pharmacology & Physiology·G J DustingA E Doyle
Dec 1, 1988·Clinical and Experimental Pharmacology & Physiology·M P RechtmanA L Boura
Jul 1, 1987·The American Review of Respiratory Disease·M A Heymann
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·B P Rowe
May 1, 1985·Prostaglandins, Leukotrienes, and Medicine·R T MasonB A Scoggins
Nov 1, 1981·British Journal of Pharmacology·G J Dusting, R D Nolan
Jul 23, 1981·Nature·R J Haslam, M D McClenaghan

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