Angiotensin IV suppresses inflammation in the brains of rats with chronic cerebral hypoperfusion

Journal of the Renin-angiotensin-aldosterone System : JRAAS
Qing-Guang WangYing-Dong Zhang

Abstract

This study aimed to evaluate the influence of central angiotensin IV (Ang IV) infusion on chronic cerebral hypoperfusion (CCH)-related neuropathological changes including amyloid-β (Aβ), hyperphosphorylated tau (p-tau) and the inflammatory response. Rats with CCH received central infusion of Ang IV, its receptor AT4R antagonist divalinal-Ang IV or artificial cerebrospinal fluid for six weeks. During this procedure, the systolic blood pressure (SBP) was monitored, and the levels of Aβ42, p-tau and pro-inflammatory cytokines in the brain were detected. Rats with CCH exhibited higher levels of Aβ42, p-tau and pro-inflammatory cytokines in the brain when compared with controls. Infusion of Ang IV significantly reduced the expression of pro-inflammatory cytokines in the brains of rats with CCH. Meanwhile, the reduction of pro-inflammatory cytokines levels caused by Ang IV was reversed by divalinal-Ang IV. During the treatment, the SBP in rats was not significantly altered. This study demonstrates for the first time that Ang IV dose-dependently suppresses inflammation through AT4R in the brains of rats with CCH, which is independent from SBP. These findings suggest that Ang IV/AT4R may represent a potential therapeutic target for CCH...Continue Reading

References

Jul 2, 2011·The Journal of Pharmacology and Experimental Therapeutics·Caroline C BenoistJoseph W Harding
Sep 29, 2011·Peptides·Aurelie Nguyen Dinh Cat, Rhian M Touyz
Dec 2, 2011·The Journal of Pharmacology and Experimental Therapeutics·Leen H KawasJoseph W Harding
Apr 27, 2012·Pflügers Archiv : European journal of physiology·John W Wright, Joseph W Harding
Oct 12, 2012·The Journal of Pharmacology and Experimental Therapeutics·Alene T McCoyJoseph W Harding
Nov 7, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Teng JiangYingdong Zhang
Feb 19, 2013·Neuropharmacology·Jason J ParisJay P McLaughlin
Sep 21, 2013·Acta Neuropathologica·Patrick L McGeer, Edith G McGeer
Dec 4, 2013·Frontiers in Endocrinology·John W WrightJoseph W Harding
Sep 12, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Isha DhandeTahir Hussain
Oct 30, 2014·Cellular and Molecular Neurobiology·Yang Zhao, Cheng-Xin Gong
Dec 3, 2014·Progress in Neurobiology·John W WrightJoseph W Harding
Dec 6, 2014·Autoimmunity Reviews·Nicolas MolnarfiPatrice H Lalive
Jan 16, 2015·Journal of Cardiovascular Pharmacology·Luis C MatavelliHelmy M Siragy
Aug 20, 2016·Science·Richard M Ransohoff
May 10, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jessika RoyeaEdith Hamel
Apr 21, 2018·Biomedical Journal·Cyril LaurentDavid Blum

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Citations

Dec 31, 2019·Protein and Peptide Letters·Victor Teatini RibeiroAna Cristina Simões E Silva
Feb 3, 2021·Hipertensión y riesgo vascular·M Molina-Van den BoschM J Soler

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

STPLAN
GraphPad Prism

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