PMID: 9179925May 1, 1997Paper

Angiotensin mediated interaction of fetal kidney and placenta in the control of fetal arterial pressure and its role in hydrops fetalis

Placenta
J Job Faber, D F Anderson

Abstract

Fetal cardiovascular control is effected by an interaction of the fetal somatic and placental circulations. Three primary regulatory mechanisms are involved: transplacental transfer of extracellular fluid, driven by a difference in hydrostatic and oncotic pressures; modulation of fetal placental and somatic vascular resistances by means of blood pressure controlled production of angiotensin; and somatic autoregulation of flow. A systems analysis incorporates these and other fetal cardiovascular functions and this analysis was modelled for computer simulation. Given physiologically plausible values for known cardiovascular parameters in the fetal sheep, the model reproduced in detail a variety of experimental protocols with known outcomes; these included the normal fetus, the fetus after bilateral nephrectomy, the nephrectomized fetus infused with angiotensin, the intact fetus infused with NaCl solutions, the fetus with lymphatic obstruction and the severely anaemic fetus. The systems analysis demonstrated that fetal cardiac failure constituted the strongest stimulus for the formation of fetal oedema of any tested pathological intervention.

References

May 1, 1992·Placenta·J J Faber, D F Anderson
Apr 1, 1991·Circulation Research·C W PinsonK L Thornburg
May 1, 1990·American Journal of Obstetrics and Gynecology·R L Andres, R A Brace
Feb 1, 1989·American Journal of Obstetrics and Gynecology·D F Anderson, J J Faber
Jun 1, 1972·The Journal of Physiology·J J Faber, T J Green
Dec 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D F AndersonJ J Faber

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Citations

Aug 26, 2003·The Journal of Physiology·A E O'ConnellK J Gibson
Mar 12, 2008·Prenatal Diagnosis·Jeroen P H M van den WijngaardMartin J C van Gemert
Mar 17, 2007·Annals of the New York Academy of Sciences·Jeroen P H M VAN DEN WijngaardMartin J C VAN Gemert
Mar 15, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Merih ÇetinkayaSultan Kavuncuoglu
Jul 20, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert A BraceDebra F Anderson
Aug 15, 2006·American Journal of Physiology. Heart and Circulatory Physiology·George D GiraudDebra F Anderson
Dec 13, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeroen P H M van den WijngaardMartin J C van Gemert
Nov 8, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J S QuaedackersL Bennet
Nov 13, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeroen P H M van den WijngaardMartin J C van Gemert
Mar 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Job FaberLowell Davis
Aug 18, 2020·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Issa Al Salmi, Suad Hannawi
May 10, 2005·Journal of Applied Physiology·George D GiraudDebra F Anderson
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·E R LumbersL Bennet
Sep 24, 2005·Experimental Biology and Medicine·Charles E WoodMaureen Keller-Wood

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