Angiotensin mediates forearm glucose uptake by hemodynamic rather than direct effects

Hypertension
K A JamersonS Julius

Abstract

Insulin sensitivity may be improved with the angiotensin-converting enzyme inhibitor captopril, suggesting that inhibition of angiotensin II (Ang II) improves insulin resistance. However, the administration of systemic Ang II has also been associated with an improvement in rather than worsening of glucose utilization. Since both stimulating and antagonizing the renin-angiotensin system improve glucose uptake and both angiotensin-converting enzyme inhibitors and intravenous Ang II elicit skeletal muscle vasodilation, it is conceivable that hemodynamic factors rather than a direct effect of either Ang II or angiotensin-converting enzyme inhibitors on skeletal muscle metabolism modulate the increase in glucose utilization. The direct effects of Ang II on glucose extraction in intact human skeletal muscle have not been previously described. We investigated the effects of local infusion of Ang II on glucose uptake in the forearm of 20 healthy subjects. With the use of the isolated insulin-perfused forearm model, local plasma insulin values were raised to 100 mU/mL over fasting values and maintained there for a 90-minute infusion period. After the first 60 minutes of insulin alone, Ang II was infused into the brachial artery for the ...Continue Reading

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Citations

May 9, 2012·Molecular and Cellular Endocrinology·Erik J Henriksen, Mujalin Prasannarong
Jun 12, 2012·Molecular and Cellular Endocrinology·Ranganath Muniyappa, Sahzene Yavuz
Aug 29, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Theodore W Kurtz, Uwe Klein
Jan 26, 2007·Clinical and Experimental Pharmacology & Physiology·Cathryn M KolkaMichael G Clark
Jan 10, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Kelly PutnamLisa A Cassis
Apr 18, 2012·The Journal of Clinical Endocrinology and Metabolism·Matthew A SauderZhenqi Liu
Mar 1, 2006·Diabetes/metabolism Research and Reviews·Eugenio Cersosimo, Ralph A DeFronzo
Sep 3, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Michiel P De BoerErik H Serné
Nov 24, 1999·The American Journal of Physiology·J M RicheyR N Bergman
Jun 11, 2003·Diabetes, Obesity & Metabolism·E J Henriksen, S Jacob
Oct 29, 2000·Journal of the American Society of Nephrology : JASN·Danilo FliserEberhard Ritz

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