Angiotensin Receptor Blocker Losartan Inhibits Spontaneous Motility of Isolated Human Ureter

European Journal of Drug Metabolism and Pharmacokinetics
S V JankovicMarina Kostic

Abstract

Ureteral motility is essential for elimination of intraluminal stones, and it may be adversely affected by cardiovascular drugs that a patient is taking chronically. The aim of our study was to test whether ACE inhibitors and an angiotensin receptor blocker may influence spontaneous contractions of isolated human ureter. Both phasic and tonic contractions of the isolated ureteral segments taken from 10 patients were measured as changes of the longitudinal tension or pressure recordings. Captopril, enalapril and losartan were separately added to the organ baths cumulatively. While enalapril (2.7 × 10-7-3.9 × 10-4 M) and captopril (6.1 × 10-7-2.7 × 10-3 M) did not affect either spontaneous activity or tone of isolated ureteral segments, losartan (2.9 × 10-7-4.2 × 10-4 M) caused concentration-dependent inhibition of spontaneous contractions of the segments (50 % effective concentration (EC50) = 13.46 ± 1.80 × 10-6 M; F = 10.72, r = 0.79, p < 0.001). Due to differences in molecular mechanism of action, angiotensin receptor blocker losartan does and ACE inhibitors captopril and enalapril do not inhibit spontaneous contractions of isolated human ureter.

References

Oct 24, 2000·Kidney International·H FujinakaI Ichikawa
Sep 8, 2001·The Journal of Urology·S Y NakadaR Saban
Jun 11, 2003·The Journal of Urology·William F SantisMaryrose P Sullivan
Jun 19, 2007·The Journal of Urology·D Mastrangelo, C E Iselin
Oct 15, 2011·Physiological Research·S M JankovicS Stefanovic

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