Angiotensin receptors and norepinephrine neuromodulation: implications of functional coupling

Regulatory Peptides
C H GelbandM K Raizada

Abstract

The objective of this review is to examine the role of neuronal angiotensin II (Ang II) receptors in vitro. Two types of G protein-coupled Ang II receptors have been identified in cardiovascularly relevant areas of the brain: the AT1 and the AT2. We have utilized neurons in culture to study the signaling mechanisms of AT1 and AT2 receptors. Neuronal AT1 receptors are involved in norepinephrine (NE) neuromodulation. NE neuromodulation can be either evoked or enhanced. Evoked NE neuromodulation involves AT1 receptor-mediated, losartan-dependent, rapid NE release, inhibition of K+ channels and stimulation of Ca2+ channels. AT1 receptor-mediated enhanced NE neuromodulation involves the Ras-Raf-MAP kinase cascade and ultimately leads to an increase in NE transporter, tyrosine hydroxylase and dopamine beta-hydroxylase mRNA transcription. Neuronal AT2 receptors signal via a Gi protein and are coupled to activation of PP2A and PLA2 and stimulation of K+ channels. Finally, putative cross-talk pathways between AT1 and AT2 receptors will be discussed.

References

Dec 1, 1992·American Journal of Hypertension·P B TimmermansR D Smith
Feb 28, 1992·Biochemical and Biophysical Research Communications·S P BottariM de Gasparo
Aug 1, 1992·Neuroreport·C StrömbergJ M Saavedra
May 1, 1992·Endocrine Reviews·J M Saavedra
Jul 15, 1992·Biochemical and Biophysical Research Communications·R GyurkoM I Phillips
Feb 1, 1986·The American Journal of Physiology·C Sumners, M K Raizada
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E J van CorvenW H Moolenaar
Jan 1, 1995·Clinical and Experimental Hypertension : CHE·A LippoldtD Ganten
Jan 1, 1995·Clinical and Experimental Hypertension : CHE·T A JenkinsF A Mendelsohn
Apr 1, 1995·Trends in Biochemical Sciences·J IngleseR J Lefkowitz
Sep 1, 1994·Frontiers in Neuroendocrinology·C SumnersP Posner
Jan 1, 1995·Trends in Biochemical Sciences·B M Burgering, J L Bos
Mar 1, 1995·The Journal of Clinical Investigation·M LoJ Sassard
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·J W Wright, J W Harding
Sep 1, 1993·The American Journal of Physiology·J KangP Posner
Jan 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L NäveriJ M Saavedra
Mar 19, 1993·Regulatory Peptides·M I PhillipsM K Raizada
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·T YamadaV J Dzau
Jan 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G Shaw
Aug 1, 1996·Circulation Research·J R MartensC H Gelband

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Citations

Jul 20, 2004·Current Hypertension Reports·Christa Thöne-ReinekeThomas Unger
Oct 31, 2001·Acta Anaesthesiologica Scandinavica·M BrooméB Biber
Mar 21, 2002·Acta Anaesthesiologica Scandinavica·M BrooméB Biber
May 16, 2002·Clinical and Experimental Pharmacology & Physiology·Colin SumnersMingyan Zhu
Feb 26, 2005·Clinical and Experimental Pharmacology & Physiology·Christian HöchtCarlos A Taira
Mar 24, 2006·Cell and Tissue Research·O von Bohlen und Halbach, D Albrecht
Dec 17, 2010·Current Opinion in Pharmacology·Lie Gao, Irving H Zucker
Jul 14, 1998·The Journal of Cell Biology·D LuM K Raizada
Mar 7, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·M GardonC H Gelband
Oct 5, 2002·Circulation Research·Hong YangMohan K Raizada
May 24, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Chanran K GantaMichael J Kenney
Jun 19, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hong YangMohan K Raizada
Dec 12, 2003·Journal of Cardiovascular Pharmacology·Alexander NapPieter A van Zwieten
Oct 2, 2002·European Journal of Biochemistry·Nduna Dzimiri
Jun 30, 2005·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Henrik WilmsRalph Lucius
May 10, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Benedek ErdosNihal Tumer
Mar 28, 2002·Anesthesia and Analgesia·Michael BrooméB Biber
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy
Feb 7, 2006·Progress in Neurobiology·Ella H SklanHermona Soreq

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