Angiotensin type 1 receptor autoantibody from preeclamptic patients induces human fetoplacental vasoconstriction

Journal of Cellular Physiology
Suli ZhangHuirong Liu

Abstract

Increased vascular resistance in the fetoplacental circulation is a characteristic of preeclampsia. However, the potential molecular mechanisms of this condition remain obscure. The current study aimed to determine the direct effect of the peptide antigen corresponding to the second extracellular loop of the angiotensin II type 1 receptor (AT1R-EC(II) ) activating autoantibody (AT1-AA), a novel risk factor in preeclamptic patients, on fetoplacental villus stem blood vessels. Immunohistochemistry revealed that AT1 receptors were localized in the veins and arteries of human placental villi. Among 58 serum samples from preeclamptic patients, 28 (48.28%) were proved AT1-AA-positive by enzyme-linked immunosorbent assay [P<0.01 vs. 2/51 (3.92%) in the normal pregnancy group]. Total IgGs purified from AT1-AA-positive patients' sera (AT1-AA-IgGs) were added to isolated normal human placental blood vessels. The IgG significantly constricted both the villus veins and arteries in a dose-dependent manner in vitro, which could be blocked by the peptide corresponding to the human AT1R-EC(II) , anti-human IgG or the AT1 receptor antagonist losartan. Additionally, the venous constriction induced by AT1-AA-IgGs remained unchanged even at the en...Continue Reading

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Citations

Jul 15, 2015·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Shikha AggarwalAnnemarie Hennessy
May 10, 2017·International Journal of Environmental Research and Public Health·Jian ZhangLe Ma
Feb 15, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alexander FichtnerBurkhard Tönshoff
Jun 10, 2015·Hypertension·Tracy Ann WilliamsMartin Reincke
Jun 28, 2016·Nature Reviews. Nephrology·Qiuheng Zhang, Elaine F Reed
Feb 24, 2020·Experimental Eye Research·Claudia Ramírez-MonteroPedro López-Sánchez
Aug 13, 2021·Proceedings of the National Academy of Sciences of the United States of America·Khuraijam Dhanachandra SinghSadashiva S Karnik

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