Angiotensinogen in human essential hypertension

Hypertension
M CaulfieldA J Clark

Abstract

The candidacy of angiotensinogen for a role in the genetic basis of hypertension is supported by the observation that plasma angiotensinogen levels track with raised blood pressure through families. In addition, transgenic mice with overexpression of a rat angiotensinogen gene develop hypertension, and knockout mice with a disrupted gene and absent angiotensinogen production develop low blood pressure. There are now two studies in populations of white European origin and one in African Caribbeans providing support for a role of the angiotensinogen gene locus in human essential hypertension.

References

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Citations

Jun 26, 2001·European Journal of Clinical Investigation·M CarluccioR De Caterina
Jul 2, 2002·Preventive Cardiology·T Rankinen, C Bouchard
Jan 13, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Huimin YuGuozhang Liu
May 24, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Leonelo E BautistaGermán Gamarra
Jan 14, 1999·Journal of Hypertension·F C Luft
Apr 1, 1999·Journal of Hypertension·J A StaessenR Fagard
Feb 28, 2008·Journal of Hypertension·Jeroen B van der NetEric Jg Sijbrands
Mar 31, 2016·Clinical and Experimental Hypertension : CHE·M SinghI S Gambhir
Jun 30, 2005·The Veterinary Journal·A R Michell
Jun 8, 2013·American Journal of Obstetrics and Gynecology·Cristiane GubermanMina Desai
Jun 21, 2006·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Lucinda Km Summers
Mar 7, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·J Zhu, D Gao
Aug 16, 2002·Physiological Genomics·Steve D McColeJames M Hagberg
Oct 19, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·F MassiéraM Teboul
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T RankinenC Bouchard
Feb 6, 2004·American Journal of Physiology. Endocrinology and Metabolism·Valérie SerazinYves Giudicelli
Apr 3, 2021·Molecular and Cellular Endocrinology·Sarfaraz AhmadCarlos M Ferrario
Feb 22, 2001·Journal of the American Society of Nephrology : JASN·Jean-Marc LalouelKenneth Ward

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