Angiotensinogen modulates renal vasculature growth

Hypertension
Marcus BrandJean-Marie Gasc

Abstract

We have shown previously that angiotensinogen, like other members of the serine protease inhibitor family, has antiangiogenic properties in vitro on cultured endothelial cells and in ovo in the chick chorioallantoic membrane assay. The aim of this study was to show the effects of angiotensinogen on vascular wall remodeling in vivo. We measured the vessel wall thickness (tunica media) stained with an antibody to alpha-actin. In the kidney, arterioles were 21.5% thinner in male transgenic mice overexpressing human angiotensinogen than in male control animals. In other vascular beds, the arterial wall thickness was not affected. By using in situ hybridization and Northern blot analysis, human angiotensinogen expression was detected at a high level in the male kidney and at a much lower level in other organs. There is a relationship between the effect of angiotensinogen on arterial wall thickness and the local expression level of angiotensinogen in this model of transgenic mice. Because human angiotensinogen is not cleaved to a significant extent by mouse renin, the reduction in kidney arterial wall thickness is because of angiotensinogen itself and not angiotensin II, and we show that the reduction was not because of hypoplasia or...Continue Reading

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Citations

Dec 21, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marcus BrandJean-Marie Gasc
Aug 19, 2007·Cardiology in Review·Reza SepehrdadDomenic A Sica
Mar 1, 2008·Clinical and Experimental Pharmacology & Physiology·A KoitkaC Tikellis
Jul 4, 2007·The Journal of Clinical Investigation·Sandrine BilletEric Clauser
Jun 22, 2013·Clinical and Experimental Hypertension : CHE·Rodrigo O MarañonMaría Peral de Bruno
Jun 1, 2008·Electrolyte & Blood Pressure : E & BP·Hyung Eun Yim, Kee Hwan Yoo
Aug 22, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Huimin YuGuozhang Liu
Dec 19, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Hong LuAlan Daugherty
Jun 26, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Ebaa M Alzayadneh, Mark C Chappell
Mar 26, 2009·Cancer Research·François VincentEvelyne Dupuy

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Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Marcus BrandJean-Marie Gasc
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