Abstract
Genetic predisposition may be underlying the prevalence of acquired atrial fibrillation (AF). We investigated the association between polymorphism in angiotensinogen (AGT) and angiotensin-converting enzyme gene and risk of acquired AF in a pair-matched case-control study conducted in Chinese Hans. We selected 9 single nucleotide polymorphisms (SNPs) in the AGT gene and 3 SNPs in the angiotensin-converting enzyme gene using a tagging-SNP strategy. We observed significant association between tagging-SNP rs699 (M235T), located in exon 2 of the AGT gene, and AF. The AA genotype of rs699 increased the risk of AF by 70% (95% confidence interval, 1.01-2.85; P = .044) under a recessive model (AA vs AG + GG). The significance remained after controlling for covariates age, smoking, body mass index, hypertension, diabetes, and left atrial dimension, with an increased risk of AF by 90% (95% confidence interval, 1.04-3.46; P = .036). We provide evidence that polymorphism in AGT gene may confer predisposition to acquired atrial fibrillation in Chinese Hans.
References
Nov 29, 1990·The New England Journal of Medicine·UNKNOWN Boston Area Anticoagulation Trial for Atrial Fibrillation InvestigatorsJ Philip Kistler
Mar 13, 1995·Archives of Internal Medicine·W M FeinbergR G Hart
Mar 27, 1997·The New England Journal of Medicine·R BrugadaR Roberts
Apr 1, 1997·The Journal of Clinical Investigation·I InoueJ M Lalouel
May 1, 1997·Hypertension·L J BloemJ H Pratt
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
May 10, 2001·JAMA : the Journal of the American Medical Association·A S GoD E Singer
Jul 30, 2002·The Journal of Biological Chemistry·Sudhir JainAshok Kumar
Oct 31, 2002·European Journal of Human Genetics : EJHG·Eva BrandFlorence Demenais
Feb 14, 2003·Bioinformatics·Lance W HahnJason H Moore
Jun 25, 2003·Journal of the American College of Cardiology·Dawood DarbarTimothy M Olson
Mar 17, 2004·Circulation·Chia-Ti TsaiYung-Zu Tseng
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Apr 15, 2005·Journal of Cardiovascular Electrophysiology·Kui HongRamon Brugada
Jun 23, 2006·The New England Journal of Medicine·Michael H GollobDonglin Bai
Jan 20, 2007·Circulation Research·Mathilda T M MommersteegVincent M Christoffels
Citations
Aug 29, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jing LiMin Pan
Jun 17, 2010·Circulation. Arrhythmia and Electrophysiology·Steven A LubitzPatrick T Ellinor
Dec 6, 2012·BMC Medicine·Steven A Lubitz, Patrick T Ellinor
Dec 6, 2012·British Journal of Clinical Pharmacology·Sarah C W MarottMarianne Benn
Oct 13, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masafumi OnoToshiji Saibara
May 11, 2016·Advances in Medical Sciences·Tadeusz OsadnikMariusz Gąsior
Mar 13, 2014·Current Opinion in Cardiology·Kui Hong, Qinmei Xiong
Sep 26, 2019·The Journal of International Medical Research·Ling LiHaiyan Li
Aug 5, 2015·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Qunshan WangYi-Gang Li
Apr 9, 2020·International Journal of Molecular Sciences·Bin LiuSándor Györke
Aug 31, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·HuiXuan WangCuiJuan Li
Dec 20, 2012·Experimental and Therapeutic Medicine·Hyun-Kyung ParkDae Jean Jo
Sep 24, 2015·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Qian LiChunjie Xiao