Angiotensinogen polymorphisms and acquired atrial fibrillation in Chinese

Journal of Electrocardiology
Qun-Shan WangXiao-Feng Wang

Abstract

Genetic predisposition may be underlying the prevalence of acquired atrial fibrillation (AF). We investigated the association between polymorphism in angiotensinogen (AGT) and angiotensin-converting enzyme gene and risk of acquired AF in a pair-matched case-control study conducted in Chinese Hans. We selected 9 single nucleotide polymorphisms (SNPs) in the AGT gene and 3 SNPs in the angiotensin-converting enzyme gene using a tagging-SNP strategy. We observed significant association between tagging-SNP rs699 (M235T), located in exon 2 of the AGT gene, and AF. The AA genotype of rs699 increased the risk of AF by 70% (95% confidence interval, 1.01-2.85; P = .044) under a recessive model (AA vs AG + GG). The significance remained after controlling for covariates age, smoking, body mass index, hypertension, diabetes, and left atrial dimension, with an increased risk of AF by 90% (95% confidence interval, 1.04-3.46; P = .036). We provide evidence that polymorphism in AGT gene may confer predisposition to acquired atrial fibrillation in Chinese Hans.

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Citations

Aug 29, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jing LiMin Pan
Jun 17, 2010·Circulation. Arrhythmia and Electrophysiology·Steven A LubitzPatrick T Ellinor
Dec 6, 2012·BMC Medicine·Steven A Lubitz, Patrick T Ellinor
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Aug 5, 2015·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Qunshan WangYi-Gang Li
Apr 9, 2020·International Journal of Molecular Sciences·Bin LiuSándor Györke
Aug 31, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·HuiXuan WangCuiJuan Li
Dec 20, 2012·Experimental and Therapeutic Medicine·Hyun-Kyung ParkDae Jean Jo

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