Angiotensinogen T235 and ACE insertion/deletion polymorphisms associated with albuminuria in Chinese type 2 diabetic patients

Diabetes Care
R P YoungC S Cockram

Abstract

Genetic polymorphisms of the renin-angiotensin system (RAS) have been implicated in the pathogenesis of diabetic proteinuria. Ethnic differences in the frequencies of these genotypes have also been reported. To date, most of these studies have been performed in white and Japanese populations. In this study, we examined the associations between albuminuria and RAS genetic polymorphisms in Chinese patients with type 2 diabetes. In a case-control study, the ACE insertion/deletion (I/D) gene, the angiotensinogen (AGT) gene (M235T), and the angiotensin II (AII) type 1 receptor gene (AT1 A1166C) were examined in 110 Chinese type 2 diabetic patients. Increased urinary albumin excretion (UAE) was defined as > or = 30 mg/day on at least two occasions during a 6-week study period. Compared with whites, there were high frequencies of the AGT TT genotype in Chinese control subjects (120/183 = 70%) and type 2 diabetic patients (74/110 = 67%). The frequencies of the MM genotype were 5 and 3%, respectively, and those of the ACE DD genotype were 13 and 10%, respectively. Although 9% of subjects carried the C allele, the AT1 CC genotype was not found in either group. Chinese type 2 diabetic patients with increased albuminuria (n = 56) had highe...Continue Reading

Citations

Sep 15, 1998·American Heart Journal·J E Sanderson
Oct 20, 2001·Diabetes Research and Clinical Practice·M ArazA Sükrü Aynacioglu
Oct 3, 2001·Diabetes Research and Clinical Practice·J C ChanC S Cockram
Jan 23, 2008·Genetical Research·Y B SaabA D J Overall
Sep 21, 2000·The Proceedings of the Nutrition Society·J Webber, I A Macdonald
Jun 30, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T Y WongP K Li
Oct 27, 2004·Nephrology·Keng-Thye WooKok-Seng Wong
Sep 24, 2005·International Journal of Clinical Practice·I DegirmenciC Demirustu
Feb 7, 2015·Diabetes Research and Clinical Practice·Terry Ting-Yu ChiouRue-Tsuan Liu
Mar 23, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Nabil MtiraouiWassim Y Almawi
Jan 4, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·Robert B Yates, Mark Stafford-Smith
Jun 17, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Edward D Levin
May 24, 2005·Nature Immunology·Scott T Weiss
Apr 26, 2003·Journal of Hypertension·Gunther WeitzChristoph Dodt
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J P Porter
Feb 11, 2000·Medizinische Klinik·T Klemm, R Paschke
Mar 7, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Donghao ZhouShengxiang Wang
Feb 1, 2015·Reproduction, Fertility, and Development·Pablo Juan Ross, Sebastian Canovas
Jun 3, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T Y WongP K Li

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