PMID: 9163872May 1, 1997Paper

Angora mouse mutation: altered hair cycle, follicular dystrophy, phenotypic maintenance of skin grafts, and changes in keratin expression

Veterinary Pathology
John P SundbergA P Bertolino

Abstract

Angora is an autosomal recessive mouse mutation caused by a deletion of approximately 2 kilobases in the fibroblast growth factor 5 (Fgf5) gene. Phenotypically, homozygous angora (Fgf5go/Fgf5go) mice have excessively long truncal hair and can be differentiated from heterozygous (+/Fgf5go) and wild-type (+/+) littermates by 21 days of age. Abnormal hair length is due to a prolongation of the anagen phase of the hair cycle of approximately 3 days. In addition, widely scattered hair follicles produce structurally defective hair shafts that twist within the follicle, presumably causing secondary hyperplasia of the outer root sheath and epidermis adjacent to the follicle. These follicular abnormalities were accentuated by immunohistochemical detection of mouse specific keratin 6, a nonspecific marker of epidermal hyperplasia. These abnormalities could be identified from birth throughout life in angora mice genotyped by polymerase chain reaction techniques. Moreover, the long truncal hair phenotype was maintained in skin grafted onto C.B-17/Sz-scid/scid mice that had normal pelage hairs and hair cycles, suggesting that circulating or diffusible humoral factors regulating the mouse hair cycle are not involved in this mutation. The ang...Continue Reading

Citations

Oct 19, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Barbara GandolfiLeslie A Lyons
Jul 16, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Yukio YonedaRyotaro Yoshida
Aug 29, 2009·Science·Edouard CadieuElaine A Ostrander
Jul 26, 2014·Annual Review of Cell and Developmental Biology·Jeffrey J Schoenebeck, Elaine A Ostrander
Jan 25, 2013·Cell and Tissue Research·Keith Brocklehurst, Mike P Philpott
Aug 17, 2005·The Journal of Cell Biology·Laura AlonsoElaine Fuchs
Jan 1, 2014·Genetics, Selection, Evolution : GSE·Romain LegrandMarie Abitbol
Nov 6, 1998·The Journal of Investigative Dermatology·K J McElweeJ P Sundberg
Mar 29, 2002·The Journal of Investigative Dermatology·T MauroE Hummler
Apr 17, 2007·Animal Genetics·C DrögemüllerT Leeb
Jun 13, 2008·The British Journal of Dermatology·A NaitoM Ohdera
Mar 13, 2014·Biological Reviews of the Cambridge Philosophical Society·Joseph N Nissimov, Asit Baran Das Chaudhuri
Oct 1, 1996·Dermatologic Clinics·J P Sundberg, L E King
Jun 15, 2000·The American Journal of Pathology·J P SundbergK Stenn
Jun 19, 2013·Scientific Reports·Barbara GandolfiLeslie A Lyons
Sep 2, 2003·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Cheng-Ming Chuong, Dominique G Homberger
Nov 21, 2017·Oncotarget·Sara GhassemiMichael Grusch
Oct 11, 2020·Nature Communications·Sarina Harshuk-ShabsoDavid Enshell-Seijffers
Feb 24, 2020·Theriogenology·Chinatsu MukaiAlexander J Travis

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