PMID: 12761244May 23, 2003Paper

AngRem104, an angiotensin II-induced novel upregulated gene in human mesangial cells, is potentially involved in the regulation of fibronectin expression

Journal of the American Society of Nephrology : JASN
Xiubin LiangHaiyan Wang

Abstract

Accumulation of extracellular matrix (ECM) in the glomerular mesangium is a common feature of many progressive renal diseases. Angiotensin II (AngII) plays important roles in the proliferation of glomerular mesangial cells (MC) as well as the synthesis of ECM such as fibronectin (FN) and collagens. However, the precise molecular signals responsible for these effects are unknown. To explore possible molecule mechanism of ECM accumulation related to AngII, suppression subtractive hybridization (SSH) was performed to screen and identify upregulated genes induced by AngII in cultured human MC. A novel gene, AngRem104 (GenBank accession number, AF367870), was isolated. The full-length cDNA of AngRem104 is 1690 bp, and it contains a 1041-bp open reading frame (ORF) encoding 347 amino acid residues with a predicted molecular mass of 37.2 kD. AngRem104 widely expressed in human heart, placenta, liver, muscle, kidney, and pancreas. Moreover, AngRem104 was found in human glomeruli and tubule by in situ hybridization. In human MC, the upregulation of AngRem104 induced by AngII was time-dependent, and it was dose-dependently blocked by AngII type 1 receptor antagonist (AT1RA), Losartan. The subcellular localization detected by AngRem104-pE...Continue Reading

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Citations

May 11, 2005·Kidney International·Mingyu LiangJennifer L Pietrusz
Nov 23, 2011·Journal of Virology·Patrick C Y WooKwok-Yung Yuen
Feb 12, 2005·Emerging Infectious Diseases·Christopher F BaslerPeter Palese
May 23, 2012·Emerging Infectious Diseases·Patrick C Y WooKwok-Yung Yuen
Mar 12, 2008·Biochemical and Biophysical Research Communications·Yanling ZhangHaiyan Wang
Apr 3, 2007·Virology·Danielle E MagoffinLin-Fa Wang
Nov 6, 2004·Virology·Henrick SchomackerAlexander C Schmidt
Oct 23, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Patrick C Y WooKwok-Yung Yuen
Apr 15, 2006·The Journal of Biological Chemistry·Xiubin LiangRaymond A Frizzell

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