Angular velocity integration in a fly heading circuit

ELife
Daniel Turner-EvansVivek Jayaraman

Abstract

Many animals maintain an internal representation of their heading as they move through their surroundings. Such a compass representation was recently discovered in a neural population in the Drosophila melanogaster central complex, a brain region implicated in spatial navigation. Here, we use two-photon calcium imaging and electrophysiology in head-fixed walking flies to identify a different neural population that conjunctively encodes heading and angular velocity, and is excited selectively by turns in either the clockwise or counterclockwise direction. We show how these mirror-symmetric turn responses combine with the neurons' connectivity to the compass neurons to create an elegant mechanism for updating the fly's heading representation when the animal turns in darkness. This mechanism, which employs recurrent loops with an angular shift, bears a resemblance to those proposed in theoretical models for rodent head direction cells. Our results provide a striking example of structure matching function for a broadly relevant computation.

References

Nov 22, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Xiaohui XieH Sebastian Seung
Aug 2, 2003·Journal of Neurophysiology·Robert W StackmanJeffrey S Taube
Jan 25, 2006·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·M Konishi
Jul 21, 2006·The Journal of Comparative Neurology·Andreas S ThumHiromu Tanimoto
Mar 8, 2007·Annual Review of Neuroscience·Jeffrey S Taube
Sep 15, 2007·Journal of Neuroscience Methods·Michael B Reiser, Michael H Dickinson
Feb 28, 2008·The Journal of Comparative Neurology·Richard W DanielsAaron DiAntonio
May 30, 2008·Nature·Kirsa NeuserRoland Strauss
Apr 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Motoharu Yoshida, Michael E Hasselmo
May 11, 2010·Current Biology : CB·John A BenderRoy E Ritzmann
Jun 8, 2010·Nature Methods·Johannes D SeeligVivek Jayaraman
Feb 23, 2012·Nature Reviews. Neuroscience·Winfried DenkMoritz Helmstaedter
Apr 3, 2012·Annual Review of Neuroscience·James J Knierim, Kechen Zhang
Oct 16, 2012·Cell Reports·Arnim JenettChristopher T Zugates
Dec 1, 2012·The Journal of Experimental Biology·Peiyuan Guo, Roy E Ritzmann
Jul 23, 2013·Nature·Tsai-Wen ChenDouglas S Kim
Oct 11, 2013·Nature·Johannes D Seelig, Vivek Jayaraman
Feb 11, 2014·Nature Methods·Nathan C KlapoetkeEdward S Boyden
Feb 25, 2014·Neuron·Kei ItoUNKNOWN Insect Brain Name Working Group
May 15, 2015·Nature·Johannes D Seelig, Vivek Jayaraman
Nov 26, 2015·Current Biology : CB·Joshua P MartinRoy E Ritzmann
Jul 12, 2016·Current Biology : CB·Adrienn G Varga, Roy E Ritzmann
Sep 16, 2016·Frontiers in Behavioral Neuroscience·George S Boyan, Yu Liu
Mar 7, 2017·Frontiers in Behavioral Neuroscience·Kyobi S Kakaria, Benjamin L de Bivort
May 6, 2017·Science·Sung Soo KimVivek Jayaraman
May 26, 2017·Nature·Jonathan GreenGaby Maimon
Jun 13, 2017·Nature Neuroscience·Yi SunVivek Jayaraman

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Citations

Jun 7, 2017·Current Biology : CB·Stanley Heinze
Dec 1, 2017·The Journal of Experimental Biology·Andrew B Barron, Jenny Aino Plath
Aug 21, 2018·ELife·Romain FranconvilleVivek Jayaraman
Aug 24, 2018·The Journal of Comparative Neurology·Basil El JundiMarie Dacke
Nov 28, 2018·Bioinspiration & Biomimetics·Mohamad AlsalmanEva Kanso
May 26, 2017·Nature·Jonathan GreenGaby Maimon
Sep 5, 2017·Nature Neuroscience·Hiroshi M Shiozaki, Hokto Kazama
Jul 19, 2019·PLoS Computational Biology·Evripidis GkaniasBarbara Webb
Oct 19, 2019·The Journal of Comparative Neurology·Joss von HadelnUwe Homberg
Apr 4, 2019·The Journal of Experimental Biology·Ronny RosnerUwe Homberg
Nov 15, 2019·Bioinspiration & Biomimetics·S C PickardN S Szczecinski
Jan 31, 2020·Journal of Neurogenetics·Rüdiger Wehner
Jan 30, 2020·The Journal of Comparative Neurology·Andrea AddenStanley Heinze
Nov 22, 2019·Nature·Yvette E FisherRachel I Wilson
Nov 22, 2019·Nature·Sung Soo KimVivek Jayaraman
Apr 29, 2020·Neural Computation·Weishun ZhongArvind Murugan
Jun 22, 2019·Nature Communications·Namsoo KimHenry H Yin
Dec 25, 2019·Annual Review of Neuroscience·Brad K Hulse, Vivek Jayaraman
Jul 7, 2020·ELife·Ioannis PisokasBarbara Webb
Feb 8, 2019·The Journal of Experimental Biology·Anna HonkanenStanley Heinze
Oct 20, 2017·Integrative and Comparative Biology·Kim L HokeDaizaburo Shizuka
Jul 25, 2019·Nature Neuroscience·Jonathan GreenGaby Maimon
Nov 2, 2019·Nature Communications·Omer ManoDamon A Clark
Aug 15, 2018·Frontiers in Psychology·Matthew B Pomaville, David D Lent
Apr 6, 2018·Genetics·Julie H Simpson, Loren L Looger
Jul 25, 2019·Physical Review. E·Hidenori Tanaka, David R Nelson
Mar 11, 2020·Frontiers in Physiology·Stav EmanuelFrederic Libersat
Jul 14, 2020·Frontiers in Neuroscience·Raphaela KreiserYulia Sandamirskaya
Jan 9, 2019·Frontiers in Computational Neuroscience·Volker Dürr, Malte Schilling
Dec 14, 2018·Frontiers in Neural Circuits·Jaison Jiro OmotoVolker Hartenstein
Sep 19, 2020·Physical Review. E·Joseph L NataleIlya Nemenman
Sep 30, 2020·Proceedings of the National Academy of Sciences of the United States of America·Frederick ZittrellUwe Homberg
Apr 21, 2018·Neural Development·Matthew Q ClarkChris Q Doe
Feb 12, 2019·Frontiers in Behavioral Neuroscience·Hanna ZwakaRandolf Menzel
Aug 14, 2020·Neuron·Grigori GuitchountsDavid Cox

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Methods Mentioned

BETA
Fluorescence
electron microscopy
dissection

Software Mentioned

SPSi
MATLAB
ScanImage
Janelia Workstation
Circular Statistics Toolbox

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