Anhedonia as a clinical correlate of inflammation in adolescents across psychiatric conditions

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
Rachel D FreedVilma Gabbay

Abstract

Peripheral inflammation has been associated with multiple psychiatric disorders, particularly with depression. However, findings remain inconsistent and unreproducible, most likely due to the disorder's heterogeneity in phenotypic presentation. Therefore, in the present study, in an effort to account for inter-individual differences in symptom severity, we utilised a dimensional approach to assess the relationships between a broad panel of inflammatory cytokines and key psychiatric symptoms (i.e. depression, anhedonia, anxiety, fatigue and suicidality) in adolescents across psychiatric disorders. We hypothesised that only anhedonia (reflecting deficits of reward function) will be associated with inflammation. Participants were 54 psychotropic medication-free adolescents with diverse psychiatric conditions and 22 healthy control (HC) adolescents, aged 12-20. We measured 41 cytokines after in vitro lipopolysaccharide stimulation. Mann-Whitney U and Spearman correlation tests examined group comparison and associations, respectively, while accounting for multiple comparisons and confounds, including depression severity adolescent. There were no group differences in cytokine levels. However, as hypothesised, within the psychiatric g...Continue Reading

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Citations

Mar 6, 2019·Stress : the International Journal on the Biology of Stress·Maximus BergerRobyn McDermott
Sep 13, 2020·Brain, Behavior, and Immunity·Manivel RengasamyRebecca B Price
Jun 25, 2021·Journal of Child and Adolescent Psychopharmacology·Qi LiuVilma Gabbay
Aug 10, 2021·Frontiers in Psychiatry·Benjamin A ElyVilma Gabbay

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