Anhedonic behavior and γ-amino butyric acid during a sensitive period in female rats exposed to early adversity

Journal of Psychiatric Research
Jodi L LukkesS L Andersen

Abstract

Early life adversity increases depressive behavior that emerges during adolescence. Sensitive periods have been associated with fewer GABAergic interneurons, especially parvalbumin (PV), brain derived growth factor, and its receptor, TrkB. Here, maternal separation (MS) and social isolation (ISO) were used to establish a sensitive period for anhedonic depression using the learned helplessness (LH) paradigm. Female Sprague-Dawley rat pups underwent MS for 4-h/day or received typical care (CON) between postnatal days 2-20; for the ISO condition, separate cohorts were individually housed between days 20-40 or served as controls (CON2). Anhedonia was defined by dichotomizing subjects into two groups based on one standard deviation of the mean number of escapes for the CON group (<14). This approach categorized 22% of CON subjects and 44% of MS subjects as anhedonic (p < 0.05), similar to the prevalence in maltreated human populations. Only 12.5% of ISO rats met criterion versus 28.5% in CON2 rats. Levels of PV and TrkB were reduced in the amygdala and prelimbic prefrontal cortex (PFC) in MS rats with <14 escapes, but elevated in behaviorally resilient MS rats (>13 escapes). The number of escapes in MS subjects significantly correla...Continue Reading

References

Apr 8, 1998·Journal of Neuroscience Methods·F S HallA Pert
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·C CaldjiM J Meaney
Nov 7, 2000·Reviews in the Neurosciences·J Lehmann, J Feldon
Mar 20, 2001·Critical Reviews in Neurobiology·G SanacoraJ H Krystal
May 7, 2003·Neuroscience and Biobehavioral Reviews·Susan L Andersen
Jul 31, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christian CaldjiMichael J Meaney
Apr 5, 2007·Nature Protocols·Sabina Berretta, Francine M Benes
Mar 11, 2008·Trends in Neurosciences·Susan L Andersen, Martin H Teicher
May 31, 2008·Synapse·Claire BloomfieldSusan Totterdell
Sep 5, 2009·Science·Nadine GogollaCyril Herry
Sep 10, 2009·Frontiers in Behavioral Neuroscience·Jodi L LukkesGina L Forster
Jan 14, 2011·The International Journal of Neuropsychopharmacology·Etienne SibilleDavid A Lewis
Mar 15, 2011·Developmental Science·N TottenhamB J Casey
Apr 20, 2011·Behavioral Neuroscience·Michael B HennessyTerrence Deak
Jun 18, 2011·Biological Psychiatry·Heather C Brenhouse, Susan L Andersen
Oct 5, 2011·Archives of General Psychiatry·Vilma GabbayDikoma C Shungu
Apr 18, 2012·The American Journal of Orthopsychiatry·Wendy D'AndreaBessel A van der Kolk
Jun 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Charlis RainekiRegina M Sullivan
Jul 11, 2012·Developmental Neuroscience·Melanie P LeussisSusan L Andersen
Sep 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Dylan G GeeNim Tottenham
Oct 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Matthew Malter CohenB J Casey
Apr 22, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·F BiggioM Serra
Nov 22, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hilary A MarusakMoriah E Thomason

❮ Previous
Next ❯

Citations

Jul 14, 2020·Experimental Brain Research·Luiza Martins Costa MalconRodrigo Grassi-Oliveira
Jan 8, 2022·Harvard Review of Psychiatry·Susan L Andersen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.