Animal aging and regulation of sympathetic nerve discharge.

Journal of Applied Physiology
M J Kenney

Abstract

Studies completed in human subjects have made seminal contributions to understanding the effects of age on sympathetic nervous system (SNS) regulation. Numerous experimental constraints limit the design of studies involving human subjects; therefore, completion of studies in animal models of aging would be expected to provide additional insight regarding mechanisms mediating age-related changes in sympathetic nerve discharge (SND) regulation. The present review assesses the current state of the literature regarding contributions from animal studies on the effects of advancing age on SND regulation, focusing primarily on studies that have used direct recordings of sympathetic nerve outflow. Few studies using direct SND recordings have been completed in animal models of aging, regardless of the fundamental component of SND regulation reviewed (basal levels, acute responsiveness, relationships between the discharges in sympathetic nerves, central neural regulation). SNS responsiveness to various acute stressors is altered in aged compared with young animals; however, mechanisms remain virtually unexplored. There is a marked dearth of studies that have used central neural microinjection techniques in conjunction with SND recordings...Continue Reading

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Citations

Sep 30, 2014·Autonomic Neuroscience : Basic & Clinical·M J Kenney
Mar 31, 2015·Autonomic Neuroscience : Basic & Clinical·R M McMurphyM J Kenney
Jul 24, 2012·Autonomic Neuroscience : Basic & Clinical·M J KenneyR J Fels
May 23, 2013·Endocrine Reviews·J BowersB A Demeneix

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