Animal and human models for studying effects of drugs on intestinal fluid transport in vivo

Journal of Pharmacological and Toxicological Methods
Fadi H Mourad

Abstract

The understanding of the physiology and pathophysiology of intestinal fluid transport has been derived from animal and human models of normal and perturbed intestines. This understanding helped in designing drugs and changing the composition of oral rehydration solutions in a targeted manner to affect intestinal fluid absorption/secretion that was tested both in vitro and in vivo before embarking on clinical trials. In this review, in vivo techniques used to study water transport in both animal and human models are described. In particular, steady state intestinal perfusion techniques, closed segment techniques, fistulous animal models, balance study models, enteropooling models, and isotope tracer models are reviewed. Advantages and drawbacks of each technique and examples where drug effects have been studied in a particular model are provided.

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Citations

Jul 9, 2013·Journal of Pharmacological and Toxicological Methods·Zhiqiang LuoLi Wei
Feb 9, 2007·Dysphagia·Kendall SharpePeter Halley
Mar 3, 2007·American Journal of Pharmaceutical Education·Lauren B Angelo
Feb 15, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Philip FleckmanJohn P Sundberg

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