Animal and human ocular surface response to a topical nonimmune mast-cell degranulating agent (compound 48/80)

American Journal of Ophthalmology
I J Udell, Mark B Abelson

Abstract

Topical application of the nonimmune selective mast-cell degranulating agent, compound 48/80, produced the signs and symptoms of ocular allergy (itching, injection, chemosis, and mucous discharge) in eight guinea pigs, eight rabbits, and nine humans. The histamine H1 receptor antagonist, antazoline phosphate, blocked itching but not vasodilation in five humans pretreated with compound 48-80. This suggests that histamine was one of the mediators released by compound 48-80-induced degranulation. Compound 48-80 may be helpful in evaluating the effects of therapeutic agents capable of modifying mast-cell degranulation and in the study of mediators involved in external ocular inflammation.

References

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Citations

Jun 7, 2003·Current Allergy and Asthma Reports·Margarita CalongeMichael E Stern
Jan 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·E KhosraviC Hariton
Jan 1, 1982·Current Eye Research·J P SmithJ M deFaller
Nov 30, 2006·The Ocular Surface·George W OuslerMark B Abelson
Feb 20, 2008·Immunology and Allergy Clinics of North America·Leonard Bielory
Jun 1, 1996·The Journal of Allergy and Clinical Immunology·P G McMenaminC McMenamin
Jan 1, 1993·Journal of Ocular Pharmacology·C BucoloS Mangiafico
Jan 1, 1986·Journal of Ocular Pharmacology·W L Davis, J A Anderson
Sep 5, 2008·Current Opinion in Allergy and Clinical Immunology·Soo Hyun Choi, Leonard Bielory
Aug 1, 1987·Acta Ophthalmologica·M R AllansmithK J Bloch
Jan 1, 1996·Ocular Immunology and Inflammation·S MillerJ Yanni
Feb 26, 2019·Pharmaceutical Research·Mihir ShahVeena Viswanath
Jan 1, 1989·Acta Ophthalmologica. Supplement·I J UdellM B Abelson
Nov 18, 2000·The Journal of Allergy and Clinical Immunology·L Bielory

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