Animal and Organoid Models of Liver Fibrosis.

Frontiers in Physiology
Yu-Long BaoShao-Wei Li

Abstract

Liver fibrosis refers to the process underlying the development of chronic liver diseases, wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive deposition and abnormal distribution of the extracellular matrix such as collagen, glycoprotein and proteoglycan in the liver. Liver fibrosis thus constitutes the pathological repair response of the liver to chronic injury. Hepatic fibrosis is a key step in the progression of chronic liver disease to cirrhosis and an important factor affecting the prognosis of chronic liver disease. Further development of liver fibrosis may lead to structural disorders of the liver, nodular regeneration of hepatocytes and the formation of cirrhosis. Hepatic fibrosis is histologically reversible if treated aggressively during this period, but when fibrosis progresses to the stage of cirrhosis, reversal is very difficult, resulting in a poor prognosis. There are many causes of liver fibrosis, including liver injury caused by drugs, viral hepatitis, alcoholic liver, fatty liver and autoimmune disease. The mechanism underlying hepatic fibrosis differs among etiologies. The establishment of an appropriate animal model of liver fibrosis is not only an important basis for t...Continue Reading

References

May 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P D HallM J Cousins
Dec 17, 1985·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T F SlaterK U Ingold
Feb 8, 1996·Biochimica Et Biophysica Acta·J George, G Chandrakasan
Apr 13, 1999·The American Journal of Physiology·S KanzlerM Blessing
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H LouisJ Devière
Nov 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H YoshijiH Fukui
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H Tsukamoto, S C Lu
Apr 24, 2003·Critical Reviews in Toxicology·Lutz W D WeberAndreas Stampfl
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elke UeberhamRolf Gebhardt
Feb 8, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·M DandriJ Petersen
May 1, 2007·World Journal of Gastroenterology : WJG·Jin-Yang HeYuan Chen
Feb 6, 2008·Toxicology·Miki KatohTsuyoshi Yokoi
Jul 5, 2008·Gene·Florian ThieringerStephan Kanzler
Oct 23, 2008·Toxicology Letters·Kwun-Nok Mimi ManKian Cheng Tan-Un
Nov 7, 2008·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·J-J ZhangH-Y Zhong
Nov 26, 2009·The Journal of Surgical Research·Jacob G KirklandCarlos U Corvera
Sep 8, 2010·Surgery·Stefan HeinrichPierre-Alain Clavien
Nov 16, 2010·Annual Review of Pathology·Virginia Hernandez-Gea, Scott L Friedman
Jan 25, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Paulo A G SoaresMaria G Carneiro-da-Cunha
Feb 26, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hiromitsu Hayashi, Takao Sakai
Apr 6, 2011·Alcoholism, Clinical and Experimental Research·Erwin GäbeleClaus Hellerbrand
May 7, 2011·Nature Medicine·Wajahat Z MehalScott L Friedman
Sep 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jingjing JiaoCostica Aloman
Dec 31, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Masaki HataNobuyuki Terada
Jan 19, 2012·World Journal of Gastroenterology : WJG·Hai-Xia WangJin Gao
Sep 27, 2012·Alcoholism, Clinical and Experimental Research·Jun-Ying ZhouAmin A Nanji
Jan 3, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Diana J LeemingMorten A Karsdal
Jan 5, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Takeki UeharaIvan Rusyn
Jan 12, 2013·International Journal of Experimental Pathology·Masahiko MatsumotoMasayuki Sudoh
Mar 2, 2013·Nature Protocols·Adeline BertolaBin Gao
Oct 22, 2013·Biochemical and Biophysical Research Communications·Keiichi KosakaKazuaki Chayama
Feb 26, 2014·Nature Reviews. Immunology·Antonella PellicoroJonathan A Fallowfield
Apr 5, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephanie MathewsBin Gao
Jun 3, 2014·BMC Gastroenterology·Tarak K ChhedaVenkataranganna V Marikunte
Jul 6, 2014·Journal of Pharmaceutical and Biomedical Analysis·Dan-Dan WeiLing-Yi Kong
Jul 19, 2014·Science·Madeline A Lancaster, Juergen A Knoblich
Aug 30, 2014·World Journal of Gastroenterology : WJG·Giada SebastianiKostas Pantopoulos
Mar 6, 2015·Journal of Visualized Experiments : JoVE·Carmen G TagRalf Weiskirchen
Apr 4, 2015·Laboratory Animals·D ScholtenR Weiskirchen
Apr 4, 2015·Laboratory Animals·F HeymannF Tacke

❮ Previous
Next ❯

Citations

Aug 20, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Basant M MorsySally N Kamel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Methods in Molecular Biology
Aashreya Ravichandra, Robert F Schwabe
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Michitaka Matsuda, Ekihiro Seki
Cellular and Molecular Gastroenterology and Hepatology
Eva Moran-Salvador, Jelena Mann
© 2021 Meta ULC. All rights reserved