Animal and translational models of SARS-CoV-2 infection and COVID-19

Mucosal Immunology
M D JohansenP M Hansbro


COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical community is in a race to define and develop effective preventions and treatments. The major features of disease are described but clinical trials have been hampered by competing interests, small scale, lack of defined patient cohorts and defined readouts. What is needed now is head-to-head comparison of existing drugs, testing of safety including in the background of predisposing chronic diseases, and the development of new and targeted preventions and treatments. This is most efficiently achieved using representative animal models of primary infection including in the background of chronic disease with validation of findings in primary human cells and tissues. We explore and discuss the diverse animal, cell and tissue models that are being used and developed and collectively recapitulate many critical aspects of disease manifestation in humans to develop and test new preventions and treatments.


Sep 1, 1988·Diabetes·R S SurwitM N Feinglos
May 16, 2003·Nature·Ron A M FouchierAlbert D M E Osterhaus
Oct 31, 2003·Nature·Byron E E MartinaAlbert D M E Osterhaus
Feb 26, 2004·Nature Medicine·Bart L HaagmansAlbert D M E Osterhaus
Mar 20, 2004·Emerging Infectious Diseases·Hana M WeingartlMarkus Czub
Jun 18, 2004·Emerging Infectious Diseases·David E SwayneThomas G Ksiazek
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·William G GlassPhilip M Murphy
Sep 29, 2004·Journal of Virology·Thomas RoweJames M Wilson
Dec 15, 2004·Journal of Virology·Anjeanette RobertsKanta Subbarao
Oct 1, 2005·Science·Wendong LiLin-Fa Wang
Feb 28, 2006·Journal of Virology·Yu-Ting YenBetty A Wu-Hsieh
Apr 12, 2006·PLoS Medicine·James V LawlerJason Paragas
Jan 16, 2007·PLoS Pathogens·Anjeanette RobertsKanta Subbarao
Oct 19, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shannon Reagan-ShawNihal Ahmad
Feb 1, 2008·Virology·Yong-Kyu ChuColleen B Jonsson
Feb 7, 2008·Emerging Infectious Diseases·Yang YangIra M Longini
Jul 1, 2008·Veterinary Pathology·J M A van den BrandT Kuiken
Sep 2, 2008·Virology·Scott R SchaecherAndrew Pekosz
Nov 15, 2008·Public Health Reports·Kathleen L MacMahonMax J Kiefer
Apr 18, 2009·American Journal of Respiratory Cell and Molecular Biology·Irene H HeijinkAndras Kapus
Feb 9, 2010·PLoS Pathogens·Saskia L SmitsBart L Haagmans
Aug 4, 2010·Emerging Infectious Diseases·Shumpei WatanabeHiroomi Akashi
Dec 3, 2010·Emerging Infectious Diseases·Philip M HansbroAeron C Hurt
Sep 17, 2011·Nature·Thomas M KeaneDavid J Adams
Feb 22, 2012·Genetics·UNKNOWN Collaborative Cross Consortium

❮ Previous
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Dec 15, 2020·Advanced Drug Delivery Reviews·Carlos Cruz-TeranSamuel K Lai
Feb 1, 2021·Stem Cell Research & Therapy·Jing KongFukai Bao
Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Loai M SaadahIman A Basheti
Jan 22, 2021·Nature·Aaron T IrvingLin-Fa Wang
Nov 28, 2020·Bioinformatics·Gabriela A MerinoGeorgina Stegmayer
Mar 7, 2021·International Journal of Molecular Sciences·Emily E F BrownTaha Azad
Mar 5, 2021·Frontiers in Genetics·Santiago Rendon-MarinJulian Ruiz-Saenz
Mar 16, 2021·EFSA Journal·UNKNOWN European Food Safety Authority and European Centre for Disease Prevention and ControlGrazina Mirinaviciute
Sep 4, 2020·Expert Opinion on Emerging Drugs·Federica Lo BelloGaetano Caramori
Mar 30, 2021·Annals of Internal Medicine·Andrea M LernerEmily J Erbelding
Apr 1, 2021·Scientific Reports·A P ArévaloM Crispo
Mar 29, 2021·Pharmacology & Therapeutics·Gang LiuPhilip M Hansbro
Apr 1, 2021·Environmental Chemistry Letters·Rossana SegretoDaoyu Zhang
Apr 17, 2021·Proceedings of the National Academy of Sciences of the United States of America·Denicar Lina Nascimento Fabris MaedaSteven L Zeichner
May 1, 2021·Journal of Biomedical Science·Ssu-Hsueh TsengChien-Fu Hung
Dec 29, 2020·ACS Biomaterials Science & Engineering·Bader M JaraiCatherine A Fromen
Jun 4, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Aureliano Stingi, Luca Cirillo
Apr 14, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Branka Miličić StanićKathryn Sandberg
May 25, 2021·Frontiers in Medicine·Mirjam KienerMarianna Kruithof-de Julio
Jun 14, 2021·Biochemical and Biophysical Research Communications·Dong-Kyun RyuSoo-Young Lee
Jun 22, 2021·Frontiers in Medicine·Arjun SharmaMarkus Bosmann
Feb 27, 2021·International Journal of Stem Cells·Jin Yu
Aug 4, 2021·British Journal of Clinical Pharmacology·Sarah N HilmerPetra Thuermann
Aug 13, 2021·Nature Communications·Geraldine NouaillesMartin Witzenrath
Aug 10, 2021·Trends in Immunology·Benjamin L RiceC Jessica E Metcalf
Aug 27, 2021·Journal of Molecular Biology·Amrita BasuKumar Sharma
Oct 9, 2021·Cell Reports·J Tyson McDonaldAfshin Beheshti

❮ Previous
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Methods Mentioned

targeted mutation
bronchoalveolar lavage

Software Mentioned


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