Animal infection studies of two recently discovered African bat paramyxoviruses, Achimota 1 and Achimota 2

Scientific Reports
Jennifer BarrLin-Fa Wang

Abstract

Bats are implicated as the natural reservoirs for several highly pathogenic viruses that can infect other animal species, including man. Here, we investigate the potential for two recently discovered bat rubulaviruses, Achimota virus 1 (AchPV1) and Achimota virus 2 (AchPV2), isolated from urine collected under urban bat (Eidolon helvum) roosts in Ghana, West Africa, to infect small laboratory animals. AchPV1 and AchPV2 are classified in the family Paramyxoviridae and cluster with other bat derived zoonotic rubulaviruses (i.e. Sosuga, Menangle and Tioman viruses). To assess the susceptibility of AchPV1 and AchPV2 in animals, infection studies were conducted in ferrets, guinea pigs and mice. Seroconversion, immunohistological evidence of infection, and viral shedding were identified in ferrets and guinea pigs, but not in mice. Infection was associated with respiratory disease in ferrets. Viral genome was detected in a range of tissues from ferrets and guinea pigs, however virus isolation was only achieved from ferret tissues. The results from this study indicate Achimota viruses (AchPVs) are able to cross the species barrier. Consequently, vigilance for infection with and disease caused by these viruses in people and domesticated...Continue Reading

References

Jun 11, 1998·Emerging Infectious Diseases·A W PhilbeyA D Hyatt
Dec 4, 2004·Nature Medicine·J S M PeirisK Y Yuen
Oct 1, 2005·Science·Wendong LiLin-Fa Wang
Dec 2, 2005·Nature·Eric M LeroyRobert Swanepoel
Feb 21, 2006·Emerging Infectious Diseases·Mark E J Woolhouse, Sonya Gowtage-Sequeria
Oct 8, 2011·PloS One·Ina SmithHume Field
Nov 4, 2011·The American Journal of Tropical Medicine and Hygiene·Kim HalpinUNKNOWN Henipavirus Ecology Research Group
Aug 24, 2012·The Journal of General Virology·Jennifer A BarrLin-Fa Wang
Feb 5, 2013·Proceedings. Biological Sciences·Angela D LuisColleen T Webb
Jan 23, 2014·Emerging Infectious Diseases·César G AlbariñoUte Ströher
Dec 23, 2015·Virology Journal·Ben HuZhengli Shi
Oct 16, 2016·EcoHealth·Sonia T HegdeEmily S Gurley
Apr 4, 2017·Journal of Infection in Developing Countries·Yeh Fong TanKenny Voon
Jun 7, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Andrew A CunninghamJames L N Wood
Jun 22, 2017·Nature·Kevin J OlivalPeter Daszak

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Citations

Oct 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·Alice J Stelfox, Thomas A Bowden
Jun 14, 2021·Journal of Comparative Pathology·Shannon G M KirejczykNicole Gottdenker

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Methods Mentioned

BETA
PCR

Software Mentioned

Geneious
GraphPad Prism
Primer Express

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