PMID: 6968908Aug 1, 1980Paper

Animal model for immune dysfunction associated with adenosine deaminase deficiency

Proceedings of the National Academy of Sciences of the United States of America
A TeddeP P Trotta

Abstract

An in vivo murine model for immunodeficiency of both B and T cells is produced by continuous intraperitoneal infusion of 2'-deoxycoformycin (DCF), a specific tightly binding inhibitor of adenosine deaminase (ADase; adenosine aminohydrolase, EC 3.5.4.4). After DCF infusion, ADase of thymus, spleen, and lymph nodes was inhibited to varying degrees ranging from 57% to 100%. Immunodeficiency under these conditions was indicated by: (i) a striking decrease in lymphocyte response to the T-cell mitogens concanavalin A and phytohemagglutinin; (ii) an impairment of delayed hypersensitivity measured by the footpad reaction; (iii) a decrease in antibody production measured in both in vivo and in vitro plaque-forming cell assay; (iv) a significant prolongation of mouse skin allograft survival after transplantation into the C57BL/6J (H-2b) strain of skin from BALB/c (H-2d) mice; and (v) a marked lymphopenia. Histological examination indicated lymphoid degeneration in the thymus, lymph nodes, and spleen with no alterations in other tissues including bone marrow, kidney, lung, gastrointestinal tract, and liver except for the occurrence of hepatitis. A decrease in the number of Thy-1-positive cells in both spleen and lymph nodes further suppor...Continue Reading

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Citations

Jan 1, 1991·International Journal of Immunopharmacology·R W LuebkeR J Smialowicz
Jan 1, 1982·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·G J PetersJ H Veerkamp
Apr 1, 1983·Antimicrobial Agents and Chemotherapy·J R WingardW H Burns
Dec 18, 2012·American Journal of Physiology. Cell Physiology·Edwin K JacksonDelbert G Gillespie
Jul 15, 1983·Cellular Immunology·J K NicholsonJ S McDougal
Apr 15, 1982·Biochemical Pharmacology·C M Smith, J F Henderson
Sep 15, 1981·Cellular Immunology·E M SordilloP P Trotta
Jan 1, 1985·Annals of the New York Academy of Sciences·G Wolberg, T P Zimmerman
Dec 7, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jacopo MariottiDaniel H Fowler
Jun 21, 1996·The Journal of Biological Chemistry·M R BlackburnR E Kellems
Jan 1, 1985·Annals of the New York Academy of Sciences·M B Cohen, R I Glazer
Jan 1, 1985·Annals of the New York Academy of Sciences·C T LumJ S Najarian
Apr 4, 2000·Endocrinology·A M RiceS A Rivkees
Sep 1, 1986·European Journal of Immunology·M CastellazziS Longacre

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