PMID: 7545297Aug 29, 1995Paper

Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors

Proceedings of the National Academy of Sciences of the United States of America
K UberlaB Oberg

Abstract

The reverse transcriptase (RT) of the human immunodeficiency virus type 1 (HIV-1) is the major target for antiretroviral therapy of the acquired immunodeficiency syndrome (AIDS). While some inhibitors exhibit activity against most retroviral RTs, others are specific for the HIV-1 enzyme. To develop an animal model for the therapy of the HIV-1 infection with RT inhibitors, the RT of the simian immunodeficiency virus (SIV) was replaced by the RT of HIV-1. Macaques infected with this SIV/HIV-1 hybrid virus developed AIDS-like symptoms and pathology. The HIV-1-specific RT inhibitor LY300046.HCl, but not zidovudine [3'-azido-3'-deoxythymidine (AZT)] delayed the appearance of plasma antigenemia in macaques infected with a high dose of the chimeric virus. Infection of macaques with the chimeric virus seems to be a valuable model to study the in vivo efficacy of new RT inhibitors, the emergence and reversal of drug resistance, the therapy of infections with drug-resistant viruses, and the efficacy of combination therapy.

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Citations

Nov 6, 2013·Antiviral Research·Lisa C RohanLin Wang
Mar 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Theodora HatziioannouPaul D Bieniasz
Sep 10, 2008·Journal of Neurovirology·Rachel WilliamsShilpa Buch
May 26, 2001·AIDS Research and Human Retroviruses·B ZuberB Oberg
Jan 1, 1997·AIDS Research and Human Retroviruses·R C Desrosiers
May 1, 1997·AIDS Research and Human Retroviruses·H LinhartK Uberla
Feb 7, 1998·AIDS Research and Human Retroviruses·C P LocherJ A Levy
Feb 22, 2011·AIDS Research and Human Retroviruses·Nicole Stolte-LeebChristiane Stahl-Hennig
Sep 10, 2011·AIDS Research and Human Retroviruses·Koen K A Van Rompay
Mar 8, 2008·ILAR Journal·Murray B Gardner, Paul A Luciw
Jan 11, 2000·AIDS·S RanjbarN Almond
May 1, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J BalzariniK Uberla
Dec 11, 1999·Journal of Medical Primatology·B RosenwirthJ L Heeney
Apr 24, 2003·Antimicrobial Agents and Chemotherapy·Angelica C GiuffreThomas W North
Oct 21, 2011·Journal of Virology·Shailesh K ChoudharyDavid M Margolis

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