PMID: 2505205Jul 1, 1989Paper

Animal model of conjunctival primary acquired melanosis

Ophthalmology
R FolbergL D Bogh

Abstract

A condition clinically identical to human conjunctival primary acquired melanosis (PAM) was induced in 16 of 20 Dutch (pigmented) rabbits after weekly topical 60-microliters applications of a 1% solution of 7,12-dimethylbenz[a]anthracene (DMBA) in acetone. Pigment stippling appeared in the conjunctiva as early as 5 weeks after the initial carcinogen application. Confluent patches of flat pigmentation appeared over the palpebral conjunctiva 18 weeks after the onset of treatment and showed progressive lateral enlargement and darkening. Histologically, a spectrum of changes from increased melanin production and melanocytic hyperplasia without atypia (resembling the human condition of PAM without atypia) through atypical melanocytic hyperplasia (resembling human PAM with atypia) was identified. The development of this model permits further investigations to explore and explain the clinically observed phenomenon of waxing and waning of PAM and its promotion to conjunctival malignant melanoma.

References

Apr 1, 1989·Ophthalmology·R FolbergT Iwamoto
Nov 1, 1986·Journal of the American Academy of Dermatology·S H Yuspa
Aug 15, 1987·International Journal of Cancer. Journal International Du Cancer·A Osterlind
Jun 1, 1984·Ophthalmology·R FolbergL E Zimmerman

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Citations

Mar 11, 1998·Survey of Ophthalmology·S Seregard
Feb 1, 1994·Mayo Clinic Proceedings·T J Liesegang
Apr 2, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Yan Qin TanVijay Pandey

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