PMID: 6413470Jul 1, 1983Paper

Animal model of isolated gonadotropin deficiency. II. Morphologic responses to LHRH immunoneutralization

Journal of Andrology
H F EnglishR J Santen

Abstract

Morphologic changes in the male reproductive system of mongrel dogs immunized against LHRH were quantitated using linear measurements and morphometric techniques at the light-microscopic level. Two experimental groups (5 nonimmunized control animals and 5 actively immunized animals) were killed 12 weeks after the primary immunization. No significant differences were observed between three immunized dogs having low LHRH antibody titers (immunized-unaffected) and the five nonimmunized control dogs. The two immunized dogs (affected) with the highest antibody titers against LHRH were characterized by atrophy and dedifferentiation of the testes, prostate, and excurrent ducts. The morphologic changes in the testes of these two dogs were striking and included an apparent arrest or significant reduction in the spermatogenic process, concurrent epithelial degeneration, and apparent diminution of Leydig cell mass. Drastic reductions in the size of the prostatic acini and epithelial cells, as well as loss of secretory granules, reflected depression of function and androgen production. Similarly, in the excurrent ducts decreases in the measured parameters and loss of regional cytoplasmic specialization denoted functional decrescence. This ...Continue Reading

References

Jan 1, 1978·International Review of Cytology·R P Bolender
Aug 1, 1977·The American Journal of Anatomy·A S Ramos, M Dym
Mar 1, 1978·Journal of Reproduction and Fertility·L DePalatisR E Falvo
Apr 1, 1975·Biology of Reproduction·C J Connell, K Christensen
Dec 1, 1971·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M Yokoyama, J P Chang
Sep 1, 1973·Journal of Reproduction and Fertility·R Jones, T D Glover
Jan 1, 1969·International Review of Cytology·E R Weibel
Jan 1, 1971·Physiological Reviews·E Steinberger
Jul 1, 1972·The Anatomical Record·R H FooteW L Hunt
Jan 1, 1980·Anatomy and Embryology·G AumüllerU Tunn

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Citations

Oct 11, 2005·American Journal of Reproductive Immunology : AJRI·Louis VargasGary R Hunnicutt
May 1, 2014·Spermatogenesis·Justin D Vidal, Katharine M Whitney

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