Animal model of the univentricular heart and single ventricular physiology

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
F RandsbaekE H Austin

Abstract

The univentricular heart complexes are a fairly common and potentially lethal set of congenital cardiac anomalies. Progress in developing new therapeutics has been hampered by a lack of suitable animal models. The authors developed a stable, closed heart preparation to systematically examine potential interventions. Using neonatal piglets (3.5-6.0 kg), a 6-mm PTFE graft was anastomosed end to end to the innominate artery and end to side to the pulmonary artery. An atrial septostomy was made, using a Rashkind septostomy catheter passed transvenously. With the same catheter, the tricuspid valve was rendered incompetent. Occlusion of the right ventricular outflow tract completed a univentricular circuit. All cardiac output exited from the left ventricle, and pulmonary blood flow was maintained via the innominate artery-to-pulmonary artery shunt. Pressure transducers measured central venous (mid inferior vena cava), aortic, and pulmonary arterial pressures. Oximetric probes recorded systemic venous and arterial oxygen saturations. Transit-time flow probes measured total cardiac output and pulmonary flows. Systemic flow was calculated by subtracting pulmonary flow from total cardiac output. This model has been completed in 30 animal...Continue Reading

References

Jul 26, 2005·The Annals of Thoracic Surgery·Marco RicciEliot Rosenkranz
Jul 1, 1996·The Annals of Thoracic Surgery·C J RiordanE H Austin
Oct 11, 2005·The Journal of Thoracic and Cardiovascular Surgery·Marco RicciEliot Rosenkranz
Aug 4, 2001·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·E H Austin

Citations

Jul 11, 1992·The Annals of Thoracic Surgery·D R JobesW I Norwood
Feb 1, 1988·The Annals of Thoracic Surgery·J D PigottW I Norwood
Jan 1, 1980·The American Journal of Cardiology·W I NorwoodS P Sanders
Nov 1, 1994·Journal of the American College of Cardiology·O BarneaW P Santamore
Nov 1, 1958·Pediatric Clinics of North America·J A NOONAN, A S NADAS

Related Concepts

Arterial Pulse Pressure
Anastomosis, Surgical
Lung
Heart-hand Syndrome, Spanish Type
Teflon
Left Ventricular Structure
Complex (molecular entity)
Diastolic Blood Pressure
Blood Flow
Polytetrafluoroethylene

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