Animal Models and Cardiac Extracellular Matrix Research

Advances in Experimental Medicine and Biology
Timothy A Hacker

Abstract

Cardiovascular disease has been the leading cause of death worldwide for the last 15 years, accounting for 15 million deaths per year. While interventions are saving more lives, more than 20% of survivors will end up in heart failure. Cell-based and other types of therapy for advanced heart and vascular disease may offer new hope for those afflicted. Although a variety of cell types are under investigation, common issues include cell survival, retention, engraftment, and proliferation. Cardiac extracellular matrix (C-ECM) has compelling features that offer advantages to not only aid cell survival, retention, engraftment, and proliferation but likely has independent therapeutic (paracrine) and mechanical effects. Animal studies and clinical trials are underway to characterize the role of C-ECM and demonstrate efficacy for acute and chronic heart disease. This chapter reviews animal models used to enhance our knowledge of C-ECMs in heart disease and its use in the treatment of heart disease.

Citations

Oct 17, 2019·International Journal of Molecular Sciences·Natalya Bildyug
Jan 19, 2021·Biotechnology Progress·Gatika AgrawalMaddaly Ravi

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Current Opinion in Cardiology
Kai C Wollert, Helmut Drexler
Annals of Internal Medicine
J E Nelson
Occupational Health & Safety
Garry Norris
Advances in Experimental Medicine and Biology
Mikayla L Hall, Brenda M Ogle
© 2022 Meta ULC. All rights reserved