Animal models for medical countermeasures to radiation exposure.

Radiation Research
Jacqueline P WilliamsWilliam H McBride

Abstract

Since September 11, 2001, there has been the recognition of a plausible threat from acts of terrorism, including radiological or nuclear attacks. A network of Centers for Medical Countermeasures against Radiation (CMCRs) has been established across the U.S.; one of the missions of this network is to identify and develop mitigating agents that can be used to treat the civilian population after a radiological event. The development of such agents requires comparison of data from many sources and accumulation of information consistent with the "Animal Rule" from the Food and Drug Administration (FDA). Given the necessity for a consensus on appropriate animal model use across the network to allow for comparative studies to be performed across institutions, and to identify pivotal studies and facilitate FDA approval, in early 2008, investigators from each of the CMCRs organized and met for an Animal Models Workshop. Working groups deliberated and discussed the wide range of animal models available for assessing agent efficacy in a number of relevant tissues and organs, including the immune and hematopoietic systems, gastrointestinal tract, lung, kidney and skin. Discussions covered the most appropriate species and strains available ...Continue Reading

References

Dec 1, 1977·Infection and Immunity·R UrbaschekB Urbaschek
Jul 1, 1978·Infection and Immunity·F M Collins, P B Carter
Jan 1, 1979·The British Journal of Radiology·E L TravisD G Hirst
Sep 1, 1975·Infection and Immunity·D E Hilmas, R O Spertzel
Jan 1, 1992·International Journal of Radiation Biology·D R DavilaP J Haley
Apr 1, 1990·International Journal of Radiation Biology·T J MacVittieL M Souza
Apr 1, 1990·International Journal of Radiation Biology·J W Hopewell
Jan 1, 1990·The Journal of the Society of Occupational Medicine·P W Brandt-RaufR M Santella
Feb 1, 1990·International Journal of Radiation Oncology, Biology, Physics·Y Abe, M Urano
Sep 1, 1989·International Journal of Radiation Oncology, Biology, Physics·N H Terry, E L Travis
Jul 1, 1989·International Journal of Radiation Biology·M E RobbinsJ W Hopewell
Oct 1, 1989·International Journal of Radiation Biology·F A StewartJ V Lebesque
Jun 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J E Moulder, B L Fish
Jun 1, 1989·International Journal of Radiation Oncology, Biology, Physics·M E RobbinsJ W Hopewell
Jul 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·I Turesson
Aug 1, 1985·Gastroenterology·E Danquechin DorvalA Dubois
Jun 1, 1988·International Journal of Radiation Oncology, Biology, Physics·M Hauer-JensenJ W Osborne
Dec 1, 1987·The British Journal of Radiology·C C LushbaughR C Ricks
Jun 1, 1986·The British Journal of Radiology·H R WithersH D Thames
Apr 1, 1974·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·D W van Bekkum, E Schotman
Jul 1, 1984·International Journal of Radiation Oncology, Biology, Physics·H B Stone
Jul 30, 1995·International Journal of Radiation Oncology, Biology, Physics·Z X LiaoS L Tucker
Aug 30, 1995·International Journal of Radiation Oncology, Biology, Physics·P RubinJ N Finkelstein
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J R Cassady
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·J L AbkowitzP Guttorp
May 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E van RongenA Baten-Wittwer
Mar 1, 1994·International Journal of Radiation Oncology, Biology, Physics·C A LawtonJ E Moulder
Feb 1, 1997·European Journal of Haematology·I ShalitI Fabian
Apr 1, 1997·Health Physics·R E GoansR C Ricks
Jan 19, 1999·The American Journal of the Medical Sciences·F L MakrauerJ Shumaker
Dec 22, 1999·International Journal of Radiation Biology·J H HongC J Wu
May 18, 2000·International Journal of Radiation Biology·J W HopewellH F Moustafa

❮ Previous
Next ❯

Citations

Jul 6, 2013·Mutation Research·Amit AlokN K Chaudhury
Dec 15, 2010·Biosecurity and Bioterrorism : Biodefense Strategy, Practice, and Science·Nathaniel HaferRichard J Hatchett
Oct 30, 2012·Carcinogenesis·Mark Steven MillerMichael T Munley
Sep 21, 2013·Journal of the National Cancer Institute·Paul Okunieff, Sadasivan Vidyasagar
Jul 31, 2012·Journal of Radiation Research·Meetha MedhoraAniko Szabo
Aug 30, 2012·Health Physics·Thomas J MacVittie
Oct 25, 2012·Health Physics·Ross McGurkZeljko Vujaskovic
Aug 30, 2012·Health Physics·P Artur PlettChristie M Orschell
Nov 28, 2013·Health Physics·Michael GarofaloThomas J MacVittie
Oct 26, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Meetha MedhoraJohn E Moulder
Aug 14, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Robert C MolthenMeetha M Medhora
Nov 1, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Terrence E RiehlWilliam F Stenson
Dec 29, 2012·International Journal of Environmental Research and Public Health·Leena Rivina, Robert Schiestl
Jan 28, 2014·The Journal of Clinical Investigation·Jung-Hyun KimShyam Biswal
Mar 22, 2011·Disaster Medicine and Public Health Preparedness·Andrea L DiCarloDavid M Weinstock
Mar 19, 2014·Nature Communications·Naoki TakemuraSatoshi Uematsu
Mar 13, 2014·FEBS Letters·Christina L GrekGautam S Ghatnekar
Oct 16, 2014·Expert Opinion on Therapeutic Patents·Vijay K SinghThomas M Seed
Mar 31, 2015·Expert Opinion on Drug Discovery·Vijay K SinghThomas J MacVittie
Feb 24, 2016·Frontiers in Oncology·Kathryn D HeldAkihisa Takahashi
Dec 2, 2015·Experimental and Therapeutic Medicine·Haiying YueRensheng Wang
Jan 15, 2016·Chemico-biological Interactions·Amit Alok, N K Chaudhury
Jun 8, 2012·International Journal of Radiation Oncology, Biology, Physics·Nancy R HunterKathy A Mason
Dec 9, 2014·EPJ Techniques and Instrumentation·Muriel BrenguesFrederic Zenhausern
Aug 19, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Carla KantaraDarrell H Carney
Jul 15, 2015·Gastroenterology·Kyle C RocheScott T Magness

❮ Previous
Next ❯

Methods Mentioned

BETA
immunodepletion
imaging techniques
X-ray

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Southern Medical Journal
Elizabeth H DonnellySyed F Naeem
Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Eric BeyJean-Jacques Lataillade
International Journal of Radiation Oncology, Biology, Physics
Swarajit N GhoshMeetha M Medhora
© 2022 Meta ULC. All rights reserved