Animal Models for Tuberculosis in Translational and Precision Medicine

Frontiers in Microbiology
Lingjun ZhanChuan Qin

Abstract

Tuberculosis (TB) is a health threat to the global population. Anti-TB drugs and vaccines are key approaches for TB prevention and control. TB animal models are basic tools for developing biomarkers of diagnosis, drugs for therapy, vaccines for prevention and researching pathogenic mechanisms for identification of targets; thus, they serve as the cornerstone of comparative medicine, translational medicine, and precision medicine. In this review, we discuss the current use of TB animal models and their problems, as well as offering perspectives on the future of these models.

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Sep 26, 2020·Frontiers in Bioengineering and Biotechnology·Samuel B BerryAshleigh B Theberge
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Methods Mentioned

BETA
Fluorescence Activated Cell Sorting
lavage
gene knockout
gene-knockout

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