Animal models of BMAA neurotoxicity: a critical review

Life Sciences
Vardan T Karamyan, Robert C Speth

Abstract

Of all the molecules reported to have toxicological effects, BMAA (beta-methylamino alanine) stands out as having the most checkered past. In the late 1960's it was reported to be a toxic component of the cycad flour consumed by Chamorros on Guam which caused the high incidence of amyotrophic lateral sclerosis (ALS) in Guam, that was associated with a Parkinson's disease-like dementia complex (ALS-PDC). However, because ALS-PDC is a slow onset disease, manifesting itself as long as 30 years following exposure to the putative neurotoxin, and only acute toxic effects of BMAA were observed in animal studies, interest in BMAA waned. A seminal study by Spencer et al., in 1987 showing neurological impairments with long-term BMAA-fed monkeys revived the hypothesis that BMAA could cause ALS-PDC. However, the amounts of BMAA used in that study were viewed as being the equivalent of a person consuming their body weight of cycad flour every day. Again, the BMAA hypothesis was discarded. Recently a third iteration of the BMAA hypothesis has been proposed. It is based on the discovery of a novel dietary source of BMAA via biomagnification of BMAA in flying foxes, once consumed in great amounts by Chamorros. Also, reports that BMAA can be in...Continue Reading

References

Apr 1, 1992·Regulatory Toxicology and Pharmacology : RTP·E J CalabreseW R Chappell
Jun 8, 1990·European Journal of Pharmacology·A CopaniF Nicoletti
Apr 13, 1990·Science·P S SpencerA C Ludolph
Sep 1, 1989·Journal of Neurochemistry·S M RossP S Spencer
Jul 1, 1989·Journal of the Neurological Sciences·P A Sillevis Smitt, J M de Jong
Oct 25, 1971·Experimental Brain Research·L T Brown
Nov 5, 1993·Science·O W Sacks
Jul 23, 1993·Science·R Stone
Oct 1, 1995·Journal of Clinical Pharmacology·H Boxenbaum, C DiLea
Aug 1, 1996·Journal of the Neurological Sciences·A C Ludolph, P S Spencer
Aug 26, 1999·Drug Metabolism Reviews·G E KisbyP Spencer
Jan 5, 2002·Science·Liangcai PengDeborah Delmer
Mar 27, 2002·Neurology·Paul Alan Cox, Oliver W Sacks
Nov 27, 2002·Neurology·Kwang-Ming ChenRobert Haddock
Aug 13, 2003·Neurology·Sandra Anne Banack, Paul Alan Cox
Jan 1, 1963·Journal of Neuropathology and Experimental Neurology·F A METTLER, G M STERN
Nov 6, 2003·Neuroscience and Biobehavioral Reviews·C A Shaw, J M B Wilson
Nov 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Paul Alan CoxSusan J Murch
Aug 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Susan J MurchSandra Anne Banack
Sep 10, 2004·Acta Neurologica Scandinavica·S J MurchO W Sacks
Dec 25, 2004·Brain Research. Developmental Brain Research·German TorresJudith M Horowitz
Mar 1, 2005·Journal of Pharmaceutical Sciences·Iftekhar Mahmood
Apr 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Paul Alan CoxBirgitta Bergman
Sep 15, 2005·Neurology·Thomas J MontineDouglas Galasko
Nov 24, 2005·Journal of Agricultural and Food Chemistry·Katherine M PhillipsMehdi Ashraf-Khorassani
Feb 7, 2006·Journal of Ethnopharmacology·Sandra Anne BanackPaul Alan Cox
Mar 3, 2006·Journal of Psychopharmacology·Neil Easton, Charles A Marsden
Apr 28, 2006·Journal of Agricultural and Food Chemistry·Antonio Jiménez-EscrigFulgencio Saura-Calixto
Jun 13, 2006·Experimental Neurology·Shyam D RaoJohn H Weiss
Jul 1, 2006·Pharmacology, Biochemistry, and Behavior·Reyniel Cruz-AguadoChristopher A Shaw
Sep 9, 2006·Journal of Veterinary Pharmacology and Therapeutics·I MahmoodR P Hunter
Sep 9, 2006·Journal of Veterinary Pharmacology and Therapeutics·M MartinezR P Hunter

❮ Previous
Next ❯

Citations

Aug 25, 2011·Amino Acids·Rosa C Cervantes CiancaVitor M Vasconcelos
Sep 15, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jason R Cannon, J Timothy Greenamyre
Aug 9, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Oskar KarlssonMalin Andersson
Oct 22, 2011·International Journal of Environmental Research and Public Health·Alexander S ChiuBrett A Neilan
Mar 1, 2015·Neuroscience·L BerntzonJ Eriksson
Mar 29, 2014·Ecotoxicology and Environmental Safety·Valeska Contardo-JaraStephan Pflugmacher
Dec 16, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·James S Metcalf, Geoffrey A Codd
Dec 16, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Esme L PurdieGeoffrey A Codd
Dec 16, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Peter B Nunn
Dec 16, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Doug Lobner
Dec 16, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Walter G Bradley
Dec 16, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Walter G Bradley, Deborah C Mash
Oct 31, 2015·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
Jan 23, 2016·Proceedings. Biological Sciences·Paul Alan CoxSandra Anne Banack
Apr 18, 2013·Toxicology and Applied Pharmacology·Oliver OkleDaniel R Dietrich
Dec 1, 2015·Toxicon : Official Journal of the International Society on Toxinology·Damien RéveillonZouher Amzil
Jan 7, 2016·Frontiers in Neuroscience·Jan Lewerenz, Pamela Maher
Aug 4, 2015·Journal of Chromatography. a·Raquel Pérez-MíguezMaría Castro-Puyana
Jul 13, 2011·Medical Hypotheses·Nicholas C FieldElijah W Stommel
Jun 22, 2010·Toxicon : Official Journal of the International Society on Toxinology·S A BanackP A Cox
Jun 24, 2010·Toxicon : Official Journal of the International Society on Toxinology·Thomas E MarlerChristopher A Shaw
Oct 14, 2009·Toxicon : Official Journal of the International Society on Toxinology·Aifeng LiZhenyu Wang
Aug 8, 2009·Toxicon : Official Journal of the International Society on Toxinology·Rómulo AráozNicole Tandeau de Marsac
Nov 13, 2015·Toxicon : Official Journal of the International Society on Toxinology·Brendan J MainKenneth J Rodgers
Mar 11, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Srdjan LopicicDusan Cemerikic
Mar 17, 2009·Toxicon : Official Journal of the International Society on Toxinology·Peter B Nunn, Malarvizhi Ponnusamy
May 19, 2012·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Nalong Tom MekdaraUlrike Katharina Müller
Jun 14, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Caroline M TannerStephen J Grate
Oct 22, 2013·Toxicon : Official Journal of the International Society on Toxinology·Maitham Ahmed Al-SammakDavid Cassada
Oct 3, 2012·Medical Hypotheses·Roberto E Sica
May 24, 2015·Environmental Toxicology and Pharmacology·Estefanía de MunckRosa M Arahuetes
Dec 19, 2012·Medical Hypotheses·Elijah W StommelTracie A Caller
Jul 31, 2012·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Joy J GotoKazuo Ikeda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Atypical Parkinsonism (MDS)

Atypical Parkinsonism presents with the same signs and symptoms of Parkinson's disease, but do not respond to typical Parkionson's disease treatment with levodopa. Atypical Parkinsonism is thought to be associated with abnormal protein buildup within brain cells. Here is the latest on Atypical Parkinsonism.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.

© 2021 Meta ULC. All rights reserved