Animal models of cholangiocarcinoma: What they teach us about the human disease

Clinics and Research in Hepatology and Gastroenterology
Massimiliano CadamuroLuca Fabris

Abstract

Despite recent advances, pathogenesis of cholangiocarcinoma, a highly lethal cancer, remains enigmatic. Furthermore, treatment options are still limited and often disappointing. For this reason, in the last few years there has been a mounting interest towards the generation of experimental models able to reproduce the main features associated with this aggressive behavior. Toxic and infestation-induced, genetically engineered and cell implantation rodent models have been generated, contributing to a deeper understanding of the complex cell biology of the tumor, sustained by multiple cell interactions and driven by a huge variety of molecular perturbations. Herein, we will overview the most relevant animal models of biliary carcinogenesis, highlighting the methodological strategy, the molecular, histological and clinical phenotypes consistent with the human condition, their particular strengths and weaknesses and the novel therapeutic approaches that have been developed.

Citations

Mar 10, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Silvestre VicentVincenzo Cardinale
Feb 23, 2020·Expert Opinion on Therapeutic Targets·Keisaku SatoGianfranco Alpini
Jul 2, 2020·Nature Reviews. Gastroenterology & Hepatology·Jesus M BanalesGregory J Gores
Nov 27, 2019·Cancers·Oihane EriceSilvestre Vicent
Jul 19, 2020·International Journal of Molecular Sciences·Raphael MohrChristoph Roderburg
Aug 23, 2020·Cancers·Annamaria MassaMassimo Aglietta
Feb 20, 2020·Cells·Keisaku SatoGianfranco Alpini
Jan 30, 2021·Expert Opinion on Investigational Drugs·Scott H Waddell, Luke Boulter
Feb 25, 2021·Expert Opinion on Investigational Drugs·Massimiliano CadamuroLuca Fabris

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